open access

Vol 84, No 11 (2013)
ARTICLES
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Prenatal diagnosis of Down syndrome in dizygotic twin pregnancy

Józef Krawczyk, Dariusz Borowski, Piotr Węgrzyn, Mirosław Wielgoś, Krzysztof Drews
DOI: 10.17772/gp/1670
·
Ginekol Pol 2013;84(11).

open access

Vol 84, No 11 (2013)
ARTICLES

Abstract

We present a case of a 33-year-old pregnant woman who had a transvaginal ultrasound performed at week 9 of gestation. A dichorionic diamniotic twin pregnancy, with symmetrically developing fetuses, was confirmed. Chromosomal defect markers (NT, NB, DV, TV) were analyzed in the first genetic test, performed according to the Fetal Medicine Foundation (FMF) criteria, and the double marker test was performed (PAPP-A protein and free beta-hCG concentrations in patient serum were determined). In the subsequent diagnostic procedures, the patient was offered and consented to amniopuncture after week 15 of gestation. The material obtained in the course of that invasive procedure allowed to identify a normal male karyotype – 46, XY in the first fetus (Fetus I). Cytogenetic analysis of the material from the second fetus (Fetus II) resulted in the diagnosis of an abnormal female karyotype – 47, XX, +21. Based on the analyzed clinical case, we present the difficulties of performing prenatal diagnosis in a dizygotic twin pregnancy. The results prove the applicability and efficacy of prenatal diagnostics tests based on the FMF criteria also in twin pregnancies.

Abstract

We present a case of a 33-year-old pregnant woman who had a transvaginal ultrasound performed at week 9 of gestation. A dichorionic diamniotic twin pregnancy, with symmetrically developing fetuses, was confirmed. Chromosomal defect markers (NT, NB, DV, TV) were analyzed in the first genetic test, performed according to the Fetal Medicine Foundation (FMF) criteria, and the double marker test was performed (PAPP-A protein and free beta-hCG concentrations in patient serum were determined). In the subsequent diagnostic procedures, the patient was offered and consented to amniopuncture after week 15 of gestation. The material obtained in the course of that invasive procedure allowed to identify a normal male karyotype – 46, XY in the first fetus (Fetus I). Cytogenetic analysis of the material from the second fetus (Fetus II) resulted in the diagnosis of an abnormal female karyotype – 47, XX, +21. Based on the analyzed clinical case, we present the difficulties of performing prenatal diagnosis in a dizygotic twin pregnancy. The results prove the applicability and efficacy of prenatal diagnostics tests based on the FMF criteria also in twin pregnancies.
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Keywords

pregnancy, twin pregnancy, Down Syndrome, PAPP-A protein

About this article
Title

Prenatal diagnosis of Down syndrome in dizygotic twin pregnancy

Journal

Ginekologia Polska

Issue

Vol 84, No 11 (2013)

DOI

10.17772/gp/1670

Bibliographic record

Ginekol Pol 2013;84(11).

Keywords

pregnancy
twin pregnancy
Down Syndrome
PAPP-A protein

Authors

Józef Krawczyk
Dariusz Borowski
Piotr Węgrzyn
Mirosław Wielgoś
Krzysztof Drews

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