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Vol 84, No 12 (2013)
ARTICLES
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Evaluation of the association between maternal HCMV viremia and the course of pregnancy and neonatal outcome

Dorota Nowakowska, Mirosława Studzińska, Patrycja Suski, Edyta Paradowska, Jan Wilczyński, Magdalena Rycel, Zuzanna Gaj
DOI: 10.17772/gp/1672
·
Ginekol Pol 2013;84(12).

open access

Vol 84, No 12 (2013)
ARTICLES

Abstract

Congenital cytomegaly is caused by intrauterine mother-to-fetus HCMV transmission and constitutes the most common vertical infection. Objectives: The aim of the study was to analyze the viremia level in maternal blood and its influence on the course and duration of pregnancy, as well as newborn condition. Material and methods: The material included blood samples collected from 117 pregnant women with serological features of HCMV infection and from 29 neonates hospitalized at DFMMG in Lodz between 1999 and 2009. The presence of HCMV DNA in the maternal and fetal blood was tested using real-time PCR. Results: Prevalence of maternal viremia was observed to increase the risk of viremia in neonates, as compared to children born to mothers with no viremia. However, lack of HCMV DNA in maternal blood does not exclude fetal infection in utero. Newborn condition assessed by Apgar scores was significantly lower in the group of infants born to mothers with serological features of acute cytomegaly (p<0.05). Conclusion: The assessment of viremia level in maternal blood can be helpful in assessing the risk of intrauterine infection in the fetus as well as in predicting the neonatal outcome of newborn.

Abstract

Congenital cytomegaly is caused by intrauterine mother-to-fetus HCMV transmission and constitutes the most common vertical infection. Objectives: The aim of the study was to analyze the viremia level in maternal blood and its influence on the course and duration of pregnancy, as well as newborn condition. Material and methods: The material included blood samples collected from 117 pregnant women with serological features of HCMV infection and from 29 neonates hospitalized at DFMMG in Lodz between 1999 and 2009. The presence of HCMV DNA in the maternal and fetal blood was tested using real-time PCR. Results: Prevalence of maternal viremia was observed to increase the risk of viremia in neonates, as compared to children born to mothers with no viremia. However, lack of HCMV DNA in maternal blood does not exclude fetal infection in utero. Newborn condition assessed by Apgar scores was significantly lower in the group of infants born to mothers with serological features of acute cytomegaly (p<0.05). Conclusion: The assessment of viremia level in maternal blood can be helpful in assessing the risk of intrauterine infection in the fetus as well as in predicting the neonatal outcome of newborn.
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Keywords

congenital infection CMV, pregnancy, human cytomegalovirus

About this article
Title

Evaluation of the association between maternal HCMV viremia and the course of pregnancy and neonatal outcome

Journal

Ginekologia Polska

Issue

Vol 84, No 12 (2013)

DOI

10.17772/gp/1672

Bibliographic record

Ginekol Pol 2013;84(12).

Keywords

congenital infection CMV
pregnancy
human cytomegalovirus

Authors

Dorota Nowakowska
Mirosława Studzińska
Patrycja Suski
Edyta Paradowska
Jan Wilczyński
Magdalena Rycel
Zuzanna Gaj

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