The role of inositol deficiency in the etiology of polycystic ovary syndrome disorders

Abstract

Inositol acts as a second messenger in insulin signaling pathway. Literature data suggest inositol deficiency in insulin-resistant women with the polycystic ovary syndrome. Supplementation of myo-inisitol decreases insulin resistance as it works as an insulin sensitizing agent. The positive role of myo-inositol in the treatment of polycystic ovary syndrome has been of increased evidence recently. The present review presents the effects of myo-inositol on the ovarian, hormonal and metabolic parameters in women with PCOS.