Incidence of proapoptotic proteins p53 and p21 in epithelial ovarian tumors

Małgorzata Gajewska; Mirosław Wielgoś; Grzegorz Panek; Janina Marczewska

doi:10.17772/gp/1700

Vol 85, No 2 (2014)

ARTICLES

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Incidence of proapoptotic proteins p53 and p21 in epithelial ovarian tumors

Małgorzata Gajewska, Mirosław Wielgoś, Grzegorz Panek, Janina Marczewska

DOI: 10.17772/gp/1700

Ginekol Pol 2014;85(2).

Vol 85, No 2 (2014)

ARTICLES

Abstract

p21 in cystadenomas, borderline tumors and ovarian cancers. The correlation between proapoptotic proteins and selected parameters of ovarian tumors was also assessed. Material and methods: The study group consisted of 66 patients operated on because of epithelial ovarian tumor. The study group was further divided into three subgroups: cystadenomas, borderline tumors and ovarian cancers. Results: The average value of p53 was the highest in the ovarian cancer group (50.12+/-39.52), whereas average value for p21 was the highest in patients with borderline tumors (24.41+/-24.43). There was a negative correlation between tumor stage and parameters of p21(+++), p21(++), p21(+) but no correlation was found between the expression of p53, p21 and histological type of ovarian cancer. Conclusion: The assessment of p53 and p21 can be expensive, but it proves to be a useful tool in difficult cases. Positive reaction to p53 can be noted in both, benign and malignant ovarian tumors, but in case of cancer its intensity is notably stronger.