open access

Vol 85, No 2 (2014)
ARTICLES
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Incidence of proapoptotic proteins p53 and p21 in epithelial ovarian tumors

Małgorzata Gajewska, Mirosław Wielgoś, Grzegorz Panek, Janina Marczewska
DOI: 10.17772/gp/1700
·
Ginekol Pol 2014;85(2).

open access

Vol 85, No 2 (2014)
ARTICLES

Abstract

p21 in cystadenomas, borderline tumors and ovarian cancers. The correlation between proapoptotic proteins and selected parameters of ovarian tumors was also assessed. Material and methods: The study group consisted of 66 patients operated on because of epithelial ovarian tumor. The study group was further divided into three subgroups: cystadenomas, borderline tumors and ovarian cancers. Results: The average value of p53 was the highest in the ovarian cancer group (50.12+/-39.52), whereas average value for p21 was the highest in patients with borderline tumors (24.41+/-24.43). There was a negative correlation between tumor stage and parameters of p21(+++), p21(++), p21(+) but no correlation was found between the expression of p53, p21 and histological type of ovarian cancer. Conclusion: The assessment of p53 and p21 can be expensive, but it proves to be a useful tool in difficult cases. Positive reaction to p53 can be noted in both, benign and malignant ovarian tumors, but in case of cancer its intensity is notably stronger.

Abstract

p21 in cystadenomas, borderline tumors and ovarian cancers. The correlation between proapoptotic proteins and selected parameters of ovarian tumors was also assessed. Material and methods: The study group consisted of 66 patients operated on because of epithelial ovarian tumor. The study group was further divided into three subgroups: cystadenomas, borderline tumors and ovarian cancers. Results: The average value of p53 was the highest in the ovarian cancer group (50.12+/-39.52), whereas average value for p21 was the highest in patients with borderline tumors (24.41+/-24.43). There was a negative correlation between tumor stage and parameters of p21(+++), p21(++), p21(+) but no correlation was found between the expression of p53, p21 and histological type of ovarian cancer. Conclusion: The assessment of p53 and p21 can be expensive, but it proves to be a useful tool in difficult cases. Positive reaction to p53 can be noted in both, benign and malignant ovarian tumors, but in case of cancer its intensity is notably stronger.
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Keywords

p53, p21, cystadenoma of ovary, borderline tumor, cancer

About this article
Title

Incidence of proapoptotic proteins p53 and p21 in epithelial ovarian tumors

Journal

Ginekologia Polska

Issue

Vol 85, No 2 (2014)

DOI

10.17772/gp/1700

Bibliographic record

Ginekol Pol 2014;85(2).

Keywords

p53
p21
cystadenoma of ovary
borderline tumor
cancer

Authors

Małgorzata Gajewska
Mirosław Wielgoś
Grzegorz Panek
Janina Marczewska

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