open access

Vol 85, No 2 (2014)
ARTICLES
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High live birth rate after conservative treatment of ectopic pregnancy with Methotrexate

Jakub Wyroba, Józef Krzysiek, Agnieszka Rajtar-Ciosek, Olga Kacalska-Janssen, Andrzej Zmaczyński, Joanna Wiatr, Tomasz Milewicz, Magdalena Pulka
DOI: 10.17772/gp/1699
·
Ginekol Pol 2014;85(2).

open access

Vol 85, No 2 (2014)
ARTICLES

Abstract

Objectives: The aim of the study was to assess fertility in patients diagnosed with ectopic pregnancy and treated with methotrexate, as well as safety and efficacy of conservative treatment. Also, risk factors of recurrent ectopic pregnancies were determined. Material and methods: The study included 86 female patients with ectopic pregnancy, hospitalized and treated in the clinic of Gynecological Endocrinology, UJCM, Cracow, between 2007 and 2011. A total of 73 patients received a single dose of MTX in the amount of 50mg/m2 of body surface area. Serum b-hCG concentration was measured on days 4 and 7. The treatment was considered successful when b-hCG concentrations dropped to less than 0.2mIU/ml without surgery. Results: Among 34 patients on follow-up, 8 (23.5%) did not attempt to conceive again, whereas 26 patients declared their wish to conceive again. The attempt proved to be successful in case of 16 women (61.53%), and they gave birth to healthy children. Average time to pregnancy was 14.9 months (SD

Abstract

Objectives: The aim of the study was to assess fertility in patients diagnosed with ectopic pregnancy and treated with methotrexate, as well as safety and efficacy of conservative treatment. Also, risk factors of recurrent ectopic pregnancies were determined. Material and methods: The study included 86 female patients with ectopic pregnancy, hospitalized and treated in the clinic of Gynecological Endocrinology, UJCM, Cracow, between 2007 and 2011. A total of 73 patients received a single dose of MTX in the amount of 50mg/m2 of body surface area. Serum b-hCG concentration was measured on days 4 and 7. The treatment was considered successful when b-hCG concentrations dropped to less than 0.2mIU/ml without surgery. Results: Among 34 patients on follow-up, 8 (23.5%) did not attempt to conceive again, whereas 26 patients declared their wish to conceive again. The attempt proved to be successful in case of 16 women (61.53%), and they gave birth to healthy children. Average time to pregnancy was 14.9 months (SD
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Keywords

ectopic pregnancy, methotrexate, fertility, conservative treatment

About this article
Title

High live birth rate after conservative treatment of ectopic pregnancy with Methotrexate

Journal

Ginekologia Polska

Issue

Vol 85, No 2 (2014)

DOI

10.17772/gp/1699

Bibliographic record

Ginekol Pol 2014;85(2).

Keywords

ectopic pregnancy
methotrexate
fertility
conservative treatment

Authors

Jakub Wyroba
Józef Krzysiek
Agnieszka Rajtar-Ciosek
Olga Kacalska-Janssen
Andrzej Zmaczyński
Joanna Wiatr
Tomasz Milewicz
Magdalena Pulka

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