Intrauterine therapy for nonimmune hydrops fetalis (NIHF) – analysis of 38 cases

Abstract

Objective: The aim of the study was to perform an audit the results of fetal therapy in cases of nonimmune hydrops fetalis (NIHF), isolated hydrothorax and isolated ascites. Methods: A total of 38 fetuses (17-35 weeks of pregnancy) were included in the study, whereas 6 patients were excluded due to abnormal karyotype. NIHF was diagnosed in 24 cases, hydrothorax in 4 cases, and ascites in 4 cases. Shunts were implanted in 26 (81%) cases and 7 (19%) participants underwent therapeutic cordocentesis. Results: After therapy anterior-posterior diameter of the right and the left lung increased to 9.6 mm (27%) and 12.4 mm (35%), respectively. Early complications were observed in 5 (16%) cases: PROM 2 (40%), fetal death 1 (20%), infection 1 (20%), and preterm delivery 1 (20%). Out of the 27 patients, 65% had a caesarian section without early complications and 35% had a vaginal delivery, with 58% at term and 42% pre-term. Conclusions: Preceding results show that intrauterine therapy significantly improves prognisis of fetuses with NIHF.