open access

Vol 85, No 3 (2014)
ARTICLES
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Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia

Ali Yavuzcan, Mete Caglar, Yusuf Ustun, Serdar Dilbaz, Elif Yidiz, Sitki Ozbilgec, Selahattin Kumru, Ismail Ozdemir
DOI: 10.17772/gp/1713
·
Ginekol Pol 2014;85(3).

open access

Vol 85, No 3 (2014)
ARTICLES

Abstract

Objectives: The aim of the study was to compare the changes in the values of leukocytes, neutrophils, lymphocytes, mean platelet volume (MPV), and systemic inflammatory response (SIR) markers (neutrophil-lymphocyte ratio/platelet-lymphocyte ratio) in patients with severe preeclampsia (PE) of healthy pregnant and non-pregnant women. Material and methods: Hematological parameters including MPV, and SIR markers [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] were compered between the between three groups comprising of women with severe PE, healthy pregnant women and healthy non-pregnant women. Results: MPV and PLR did not show statistically significant differences between the three groups (p=0.081, p=0.098). NLR showed a statistically significant difference between the three groups (p=0.000). NLR values of patients with severe PE were statistically significantly higher than healthy non-pregnant women (p=0.000). No statistically significant difference was found between patients with severe PE and healthy pregnant women (p=0.721). The cut-off value of the leukocyte number for severe PE was 7.6 x 103/ml, with 76.7% sensitivity and 60.6% specificity. The cut-off value of neutrophil number was 6.4 x 103/ml for the group with severe PE, with 76.7% sensitivity and 69% specificity. Conclusions: Our results showed that MPV level did not differ among patients with severe PE, healthy pregnant women and non-pregnant women. NLR cannot be used to identify patients with severe PE. PLR measured before termination of pregnancy is not an effective marker for severe PE, either.

Abstract

Objectives: The aim of the study was to compare the changes in the values of leukocytes, neutrophils, lymphocytes, mean platelet volume (MPV), and systemic inflammatory response (SIR) markers (neutrophil-lymphocyte ratio/platelet-lymphocyte ratio) in patients with severe preeclampsia (PE) of healthy pregnant and non-pregnant women. Material and methods: Hematological parameters including MPV, and SIR markers [neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR)] were compered between the between three groups comprising of women with severe PE, healthy pregnant women and healthy non-pregnant women. Results: MPV and PLR did not show statistically significant differences between the three groups (p=0.081, p=0.098). NLR showed a statistically significant difference between the three groups (p=0.000). NLR values of patients with severe PE were statistically significantly higher than healthy non-pregnant women (p=0.000). No statistically significant difference was found between patients with severe PE and healthy pregnant women (p=0.721). The cut-off value of the leukocyte number for severe PE was 7.6 x 103/ml, with 76.7% sensitivity and 60.6% specificity. The cut-off value of neutrophil number was 6.4 x 103/ml for the group with severe PE, with 76.7% sensitivity and 69% specificity. Conclusions: Our results showed that MPV level did not differ among patients with severe PE, healthy pregnant women and non-pregnant women. NLR cannot be used to identify patients with severe PE. PLR measured before termination of pregnancy is not an effective marker for severe PE, either.
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Keywords

Leukocytes, mean platelet volume, neutrophilis, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, preeclampsia

About this article
Title

Mean Platelet Volume, Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio in Severe Preeclampsia

Journal

Ginekologia Polska

Issue

Vol 85, No 3 (2014)

DOI

10.17772/gp/1713

Bibliographic record

Ginekol Pol 2014;85(3).

Keywords

Leukocytes
mean platelet volume
neutrophilis
neutrophil-lymphocyte ratio
platelet-lymphocyte ratio
preeclampsia

Authors

Ali Yavuzcan
Mete Caglar
Yusuf Ustun
Serdar Dilbaz
Elif Yidiz
Sitki Ozbilgec
Selahattin Kumru
Ismail Ozdemir

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