open access

Vol 85, No 5 (2014)
ARTICLES
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Screening for ovarian cancer in BRCA1/BRCA2 mutations carriers

Agnieszka Synowiec, Gabriel Wcisło, Lubomir Bodnar, Cezary Szczylik, Agnieszka Gąsowska-Bodnar
DOI: 10.17772/gp/1735
·
Ginekol Pol 2014;85(5).

open access

Vol 85, No 5 (2014)
ARTICLES

Abstract

Worldwide screening for early detection of ovarian cancer in both, the general population and the group of women at high risk for ovarian cancer, including BRCA genes mutations carriers, has proven to be ineffective. The recommended screening methods, including a pelvic examination, transvaginal ultrasound, and CA125 performed biannually, continue to fail due to their relatively low sensitivity, specificity and positive predictive value tests, as well as the fact that cancer is still detected in advanced stages (FIGO III/IV). However, proteomic techniques and the ongoing search for more sensitive and specific biomarkers to increase effectiveness of screening tests for ovarian cancer bring new hope. We reviewed the current literature on screening for ovarian cancer in BRCA genes mutations carriers.

Abstract

Worldwide screening for early detection of ovarian cancer in both, the general population and the group of women at high risk for ovarian cancer, including BRCA genes mutations carriers, has proven to be ineffective. The recommended screening methods, including a pelvic examination, transvaginal ultrasound, and CA125 performed biannually, continue to fail due to their relatively low sensitivity, specificity and positive predictive value tests, as well as the fact that cancer is still detected in advanced stages (FIGO III/IV). However, proteomic techniques and the ongoing search for more sensitive and specific biomarkers to increase effectiveness of screening tests for ovarian cancer bring new hope. We reviewed the current literature on screening for ovarian cancer in BRCA genes mutations carriers.
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Keywords

BRCA1, BRCA2, CA125, USG TV, ovarian cancer, screening

About this article
Title

Screening for ovarian cancer in BRCA1/BRCA2 mutations carriers

Journal

Ginekologia Polska

Issue

Vol 85, No 5 (2014)

DOI

10.17772/gp/1735

Bibliographic record

Ginekol Pol 2014;85(5).

Keywords

BRCA1
BRCA2
CA125
USG TV
ovarian cancer
screening

Authors

Agnieszka Synowiec
Gabriel Wcisło
Lubomir Bodnar
Cezary Szczylik
Agnieszka Gąsowska-Bodnar

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