open access

Vol 85, No 6 (2014)
ARTICLES
Get Citation

Umbilical cord blood NGAL concentration as an early marker of perinatal asphyxia in neonates

Piotr Surmiak, Małgorzata Baumert, Małgorzata Fiala, Kinga Sypniewska, Zofia Walencka, Agnieszka Łukomska, Karolina Karcz
DOI: 10.17772/gp/1747
·
Ginekol Pol 2014;85(6).

open access

Vol 85, No 6 (2014)
ARTICLES

Abstract

Introduction: Recent reports have revealed increased concentration of neutrophil gelatinase-associated lipocalin (NGAL) in cardiovascular diseases and after episodes of hypoxia. We hypothesized that elevated plasma NGAL levels could be a result of vascular endothelial injury due to perinatal asphyxia. Materials and methods: Ninety-three newborns with a gestational age ≥37 weeks, of which 32 newborns were asphyxiated (study group), and 61 were healthy children (control group), were enrolled in the study. Serum NGAL, lactate and creatinine concentrations, acid-base balance, neutrophil and white blood cell count were measured in the umbilical cord blood. Results: Asphyxiated newborns had a significantly lower pH value (7.0 vs. 7.3; p<0.001), lower HCO3 (15.8mmol/L vs. 23.2mmol/L; p<0.001) and higher lactate concentrations (7.5mmol/L vs. 2.3mmol/L; p<0.001), as compared to controls. Neutrophil count (10.3x109/L vs. 6.5x109/L; p=0.02) and NGAL concentration (122.5ng/mL vs. 24.3ng/mL p<0.001) were elevated in asphyxiated newborns as compared to healthy children. Conclusions: The measurement of NGAL in the umbilical blood can be a valuable biomarker of perinatal asphyxia in neonates. Key words: newborn / asphyxia / NGAL /

Abstract

Introduction: Recent reports have revealed increased concentration of neutrophil gelatinase-associated lipocalin (NGAL) in cardiovascular diseases and after episodes of hypoxia. We hypothesized that elevated plasma NGAL levels could be a result of vascular endothelial injury due to perinatal asphyxia. Materials and methods: Ninety-three newborns with a gestational age ≥37 weeks, of which 32 newborns were asphyxiated (study group), and 61 were healthy children (control group), were enrolled in the study. Serum NGAL, lactate and creatinine concentrations, acid-base balance, neutrophil and white blood cell count were measured in the umbilical cord blood. Results: Asphyxiated newborns had a significantly lower pH value (7.0 vs. 7.3; p<0.001), lower HCO3 (15.8mmol/L vs. 23.2mmol/L; p<0.001) and higher lactate concentrations (7.5mmol/L vs. 2.3mmol/L; p<0.001), as compared to controls. Neutrophil count (10.3x109/L vs. 6.5x109/L; p=0.02) and NGAL concentration (122.5ng/mL vs. 24.3ng/mL p<0.001) were elevated in asphyxiated newborns as compared to healthy children. Conclusions: The measurement of NGAL in the umbilical blood can be a valuable biomarker of perinatal asphyxia in neonates. Key words: newborn / asphyxia / NGAL /
Get Citation

Keywords

newborn, asphyxia, NGAL

About this article
Title

Umbilical cord blood NGAL concentration as an early marker of perinatal asphyxia in neonates

Journal

Ginekologia Polska

Issue

Vol 85, No 6 (2014)

DOI

10.17772/gp/1747

Bibliographic record

Ginekol Pol 2014;85(6).

Keywords

newborn
asphyxia
NGAL

Authors

Piotr Surmiak
Małgorzata Baumert
Małgorzata Fiala
Kinga Sypniewska
Zofia Walencka
Agnieszka Łukomska
Karolina Karcz

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl