Maternal serum amyloid A levels in pregnancies complicated with preterm prelabour rupture of membranes

Abstract

Objective: The aim of the study was to investigate a possible association between maternal serum amyloid A levels (SAA) and maternal and fetal parameters in pregnancies complicated with preterm prelabor rupture of membranes (PPROM). Material and methods: A total of 88 pregnant women (PPROM group, n=44 and control group, n=44) were included into this prospective case control study. Serum blood samples for SAA were obtained from both groups within 1h since the rupture of the membranes and before administration of any medicine. The samples were kept frozen at -70°C until the analysis. The recorded risk factors were: age, gravidity, parity, delivery mode, gender, fetal birth weight, APGAR scores, white blood cell count, microCRP, neutrophil/lymphocyte ratio (NLR), and maternal serum SAA levels. Results: Demographic characteristics showed no statistically significant differences between the groups (p>0.05). The mode of delivery mode was cesarean section: 41% and 43.2% in the study and the control group, respectively, and this difference was statistically significant between the groups (p<0.05). Fetal parameters also showed statistically significant differences (p<0.05). There was a statistically significant difference between the groups in terms of micro CRP, NLR and SAA. SAA levels were higher in the PPROM group (p<0.005). SAA levels at a cut-off 95.63 ng/ml. Conclusion: We are of the opinion that second trimester maternal serum SAA level may be a predictive marker for PPROM. However, further studies with more participants are required.