Vol 85, No 7 (2014)
ARTICLES
Maternal serum amyloid A levels in pregnancies complicated with preterm prelabour rupture of membranes
Sezen Bozkurt Köseoğlu, Ali Irfan Guzel, Ruya Deveer, Aytekin Tokmak, Yaprak Engin-Ustun, Sibel Özdas, Nuri Danışman
DOI: 10.17772/gp/1763
·
Ginekol Pol 2014;85(7).
Vol 85, No 7 (2014)
ARTICLES
Abstract
Objective: The aim of the study was to investigate a possible association between maternal serum amyloid A levels (SAA) and maternal and fetal parameters in pregnancies complicated with preterm prelabor rupture of membranes (PPROM). Material and methods: A total of 88 pregnant women (PPROM group, n=44 and control group, n=44) were included into this prospective case control study. Serum blood samples for SAA were obtained from both groups within 1h since the rupture of the membranes and before administration of any medicine. The samples were kept frozen at -70°C until the analysis. The recorded risk factors were: age, gravidity, parity, delivery mode, gender, fetal birth weight, APGAR scores, white blood cell count, microCRP, neutrophil/lymphocyte ratio (NLR), and maternal serum SAA levels. Results: Demographic characteristics showed no statistically significant differences between the groups (p>0.05). The mode of delivery mode was cesarean section: 41% and 43.2% in the study and the control group, respectively, and this difference was statistically significant between the groups (p<0.05). Fetal parameters also showed statistically significant differences (p<0.05). There was a statistically significant difference between the groups in terms of micro CRP, NLR and SAA. SAA levels were higher in the PPROM group (p<0.005). SAA levels at a cut-off 95.63 ng/ml. Conclusion: We are of the opinion that second trimester maternal serum SAA level may be a predictive marker for PPROM. However, further studies with more participants are required.
Abstract
Objective: The aim of the study was to investigate a possible association between maternal serum amyloid A levels (SAA) and maternal and fetal parameters in pregnancies complicated with preterm prelabor rupture of membranes (PPROM). Material and methods: A total of 88 pregnant women (PPROM group, n=44 and control group, n=44) were included into this prospective case control study. Serum blood samples for SAA were obtained from both groups within 1h since the rupture of the membranes and before administration of any medicine. The samples were kept frozen at -70°C until the analysis. The recorded risk factors were: age, gravidity, parity, delivery mode, gender, fetal birth weight, APGAR scores, white blood cell count, microCRP, neutrophil/lymphocyte ratio (NLR), and maternal serum SAA levels. Results: Demographic characteristics showed no statistically significant differences between the groups (p>0.05). The mode of delivery mode was cesarean section: 41% and 43.2% in the study and the control group, respectively, and this difference was statistically significant between the groups (p<0.05). Fetal parameters also showed statistically significant differences (p<0.05). There was a statistically significant difference between the groups in terms of micro CRP, NLR and SAA. SAA levels were higher in the PPROM group (p<0.005). SAA levels at a cut-off 95.63 ng/ml. Conclusion: We are of the opinion that second trimester maternal serum SAA level may be a predictive marker for PPROM. However, further studies with more participants are required.
Title
Maternal serum amyloid A levels in pregnancies complicated with preterm prelabour rupture of membranes
Journal
Ginekologia Polska
Issue
Vol 85, No 7 (2014)
Page views
830
Article views/downloads
1050
DOI
10.17772/gp/1763
Bibliographic record
Ginekol Pol 2014;85(7).
Authors
Sezen Bozkurt Köseoğlu
Ali Irfan Guzel
Ruya Deveer
Aytekin Tokmak
Yaprak Engin-Ustun
Sibel Özdas
Nuri Danışman