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Vol 85, No 7 (2014)
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Reference values for placental growth factor (PlGF) concentration and uterine artery Doppler pulsatility index (PI) at 11–13+6 weeks of gestation in the Polish population

Przemysław Kosiński, Szymon Kozłowski, Michał Lipa, Mirosław Wielgoś, Dorota A. Bomba-Opoń, Bartosz Kaczyński, Monika Zbucka-Krętowska, Sławomir Ławicki, Maciej Szmitkowski, Sławomir Wołczyński, Robert Brawura Biskupski Samaha
DOI: 10.17772/gp/1758
·
Ginekol Pol 2014;85(7).

open access

Vol 85, No 7 (2014)
ARTICLES

Abstract

Objectives: The aim of the study was to determine placental growth factor (PlGF) concentration and uterine artery (UtA) Doppler pulsatility index (PI) at 11–13+6 weeks of gestation in the Polish population. Material and methods: A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11–13+6 weeks of gestation. All participants completed a questionnaire about their medical history, demographicsand current pregnancy. Mean arterial pressure (MAP) was calculated. Gestational age was confirmed by CRL and mean UtA PI was calculated. Blood samples were taken to measure beta HCG, PAPP-A and PlGF concentrations. Results: Out of the 577 analyzed participants, 60 (10.4%) were found to have abnormal placentation disorders (20 – hypertensive disorders and 40 – IUGR). The patients were subdivided into two groups, depending on pregnancy utcome: unaffected (n=517) and affected (n=60). The study did not confirm the anticipated correlation between maternal BMI and PlGF, but the concentration of PlGF was significantly increased in smokers. UtA PI values were not statistically significantly different depending on maternal age, BMI, method of conception, smoking or parity. The study confirms that both, UtA PI and PlGF concentrations are CRL-dependent. Median MoM values for PlGF and UtA PI were obtained for each set of CRL measurements. Median PIGF MoM was decreased in pregnancies complicated by hypertensive disorders and IUGR as compared to the unaffected group. Conclusions: The established reference ranges for UtA PI and PlGF at 11–13+6 weeks of gestation may be of clinical value in predicting placenta-associated diseases in early stages of pregnancy in the Polish population.

Abstract

Objectives: The aim of the study was to determine placental growth factor (PlGF) concentration and uterine artery (UtA) Doppler pulsatility index (PI) at 11–13+6 weeks of gestation in the Polish population. Material and methods: A prospective study was performed in pregnant women who underwent routine ultrasound scan at 11–13+6 weeks of gestation. All participants completed a questionnaire about their medical history, demographicsand current pregnancy. Mean arterial pressure (MAP) was calculated. Gestational age was confirmed by CRL and mean UtA PI was calculated. Blood samples were taken to measure beta HCG, PAPP-A and PlGF concentrations. Results: Out of the 577 analyzed participants, 60 (10.4%) were found to have abnormal placentation disorders (20 – hypertensive disorders and 40 – IUGR). The patients were subdivided into two groups, depending on pregnancy utcome: unaffected (n=517) and affected (n=60). The study did not confirm the anticipated correlation between maternal BMI and PlGF, but the concentration of PlGF was significantly increased in smokers. UtA PI values were not statistically significantly different depending on maternal age, BMI, method of conception, smoking or parity. The study confirms that both, UtA PI and PlGF concentrations are CRL-dependent. Median MoM values for PlGF and UtA PI were obtained for each set of CRL measurements. Median PIGF MoM was decreased in pregnancies complicated by hypertensive disorders and IUGR as compared to the unaffected group. Conclusions: The established reference ranges for UtA PI and PlGF at 11–13+6 weeks of gestation may be of clinical value in predicting placenta-associated diseases in early stages of pregnancy in the Polish population.
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Keywords

Doppler studies, uterine artery pulsatility index, placental growth factor

About this article
Title

Reference values for placental growth factor (PlGF) concentration and uterine artery Doppler pulsatility index (PI) at 11–13+6 weeks of gestation in the Polish population

Journal

Ginekologia Polska

Issue

Vol 85, No 7 (2014)

DOI

10.17772/gp/1758

Bibliographic record

Ginekol Pol 2014;85(7).

Keywords

Doppler studies
uterine artery pulsatility index
placental growth factor

Authors

Przemysław Kosiński
Szymon Kozłowski
Michał Lipa
Mirosław Wielgoś
Dorota A. Bomba-Opoń
Bartosz Kaczyński
Monika Zbucka-Krętowska
Sławomir Ławicki
Maciej Szmitkowski
Sławomir Wołczyński
Robert Brawura Biskupski Samaha

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