open access

Vol 85, No 8 (2014)
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Relation of inflammatory markers with both presence and severity of hyperemesis gravidarum

Raziye Keskin Kurt, Ayşe Güler, Dilek Benk Silfeler, Mustafa Doğan Özçil, Atilla Karateke, Ali Ulvi Hakverdi
DOI: 10.17772/gp/1776
·
Ginekol Pol 2014;85(8).

open access

Vol 85, No 8 (2014)
ARTICLES

Abstract

Objectives: The aim of our study is to determine the newly introduced systemic inflammation marker, neutrophil lymphocyte ratio (NLR) in hyperemesis gravidarum (HG) patients and to investigate the association between severity of the disease and NLR. Method: The study population consisted of 55 pregnant patients with HG and 50 pregnant women without complaints matched for gestational age as a control group. The HG patients were grouped as mild (n=16), moderate (n=19) and severe (n=20) according to Modified Pregnancy- Unique Quantification of Emesis and Nausea Scoring Index Questionnaire. Furthermore, hsCRP, neutrophils, lymphocytes, and NLR were evaluated with complete blood count. Results: The HG group had significantly higher NLR values compared to the control group (2.69±1.81 vs 1.97±1.34, p=0.004). HsCRP levels were significantly higher among HG patients compared to the control group (1.95±2.2 vs 0.56±0.30, p<0.001). The subgroup analysis revealed statistically significant increases in NLR and hsCRP values with increased HG severity (p<0.001, p=0.002). The correlation analysis demonstrated a strong correlation between NLR and hsCRP levels (r: 0.703, p<0.001). Conclusion: Our study results showed that NLR and hsCRP levels are increased in HG disease compared to gestational age matched control group subjects. Furthermore, NLR and hsCRP values are correlated with severity of disease. NLR could be used as a marker for both presence and severity of hyperemesis gravidarum.

Abstract

Objectives: The aim of our study is to determine the newly introduced systemic inflammation marker, neutrophil lymphocyte ratio (NLR) in hyperemesis gravidarum (HG) patients and to investigate the association between severity of the disease and NLR. Method: The study population consisted of 55 pregnant patients with HG and 50 pregnant women without complaints matched for gestational age as a control group. The HG patients were grouped as mild (n=16), moderate (n=19) and severe (n=20) according to Modified Pregnancy- Unique Quantification of Emesis and Nausea Scoring Index Questionnaire. Furthermore, hsCRP, neutrophils, lymphocytes, and NLR were evaluated with complete blood count. Results: The HG group had significantly higher NLR values compared to the control group (2.69±1.81 vs 1.97±1.34, p=0.004). HsCRP levels were significantly higher among HG patients compared to the control group (1.95±2.2 vs 0.56±0.30, p<0.001). The subgroup analysis revealed statistically significant increases in NLR and hsCRP values with increased HG severity (p<0.001, p=0.002). The correlation analysis demonstrated a strong correlation between NLR and hsCRP levels (r: 0.703, p<0.001). Conclusion: Our study results showed that NLR and hsCRP levels are increased in HG disease compared to gestational age matched control group subjects. Furthermore, NLR and hsCRP values are correlated with severity of disease. NLR could be used as a marker for both presence and severity of hyperemesis gravidarum.
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Keywords

Hyperemesis Gravidarum, inflammation, Neutrophil to lymphocyte ratio, hsCRPl

About this article
Title

Relation of inflammatory markers with both presence and severity of hyperemesis gravidarum

Journal

Ginekologia Polska

Issue

Vol 85, No 8 (2014)

DOI

10.17772/gp/1776

Bibliographic record

Ginekol Pol 2014;85(8).

Keywords

Hyperemesis Gravidarum
inflammation
Neutrophil to lymphocyte ratio
hsCRPl

Authors

Raziye Keskin Kurt
Ayşe Güler
Dilek Benk Silfeler
Mustafa Doğan Özçil
Atilla Karateke
Ali Ulvi Hakverdi

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