Vol 85, No 9 (2014)
ARTICLES
Chemosensitivity testing in ovarian cancer – prospects for the future
Paulina Pogońska, Dariusz Wydra, Juliusz Kobierski, Anna Łojkowska, Krystyna Serkies
DOI: 10.17772/gp/1794
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Ginekol Pol 2014;85(9).
Vol 85, No 9 (2014)
ARTICLES
Abstract
Individualization of treatment on the basis of in vitro chemosensitivity testing constitutes one of the aims of contemporary oncology. Although previous studies report advantages resulting from chemosensitivity laboratory tests, the issue remains an area of interest. The aim of this study was to discuss chemosensitivity assay methods of ovarian cancer cells. ATP-TCA (ATP-based tumor chemosensitivity assay) is the most investigated chemosensitivity test in ovarian cancer, with well-documented efficacy. Potentially, it is possible to use the xCELLigence system to evaluate chemosensitivity of ovarian cancer cells by measuring their colony volume but application of this method remains in the experimental phase. Optimization of ovarian cancer treatment would improve chemotherapy results, thus increasing the overall survival, improving the quality of patient life, decreasing chemotherapy-related toxicity and resulting in economic benefits owing to better drug use.
Abstract
Individualization of treatment on the basis of in vitro chemosensitivity testing constitutes one of the aims of contemporary oncology. Although previous studies report advantages resulting from chemosensitivity laboratory tests, the issue remains an area of interest. The aim of this study was to discuss chemosensitivity assay methods of ovarian cancer cells. ATP-TCA (ATP-based tumor chemosensitivity assay) is the most investigated chemosensitivity test in ovarian cancer, with well-documented efficacy. Potentially, it is possible to use the xCELLigence system to evaluate chemosensitivity of ovarian cancer cells by measuring their colony volume but application of this method remains in the experimental phase. Optimization of ovarian cancer treatment would improve chemotherapy results, thus increasing the overall survival, improving the quality of patient life, decreasing chemotherapy-related toxicity and resulting in economic benefits owing to better drug use.
Keywords
ovarian cancer, chemotherapy
Title
Chemosensitivity testing in ovarian cancer – prospects for the future
Journal
Ginekologia Polska
Issue
Vol 85, No 9 (2014)
Page views
824
Article views/downloads
1443
DOI
10.17772/gp/1794
Bibliographic record
Ginekol Pol 2014;85(9).
Keywords
ovarian cancer
chemotherapy
Authors
Paulina Pogońska
Dariusz Wydra
Juliusz Kobierski
Anna Łojkowska
Krystyna Serkies
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