open access

Vol 85, No 9 (2014)
ARTICLES
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Chemosensitivity testing in ovarian cancer – prospects for the future

Paulina Pogońska, Dariusz Wydra, Juliusz Kobierski, Anna Łojkowska, Krystyna Serkies
DOI: 10.17772/gp/1794
·
Ginekol Pol 2014;85(9).

open access

Vol 85, No 9 (2014)
ARTICLES

Abstract

Individualization of treatment on the basis of in vitro chemosensitivity testing constitutes one of the aims of contemporary oncology. Although previous studies report advantages resulting from chemosensitivity laboratory tests, the issue remains an area of interest. The aim of this study was to discuss chemosensitivity assay methods of ovarian cancer cells. ATP-TCA (ATP-based tumor chemosensitivity assay) is the most investigated chemosensitivity test in ovarian cancer, with well-documented efficacy. Potentially, it is possible to use the xCELLigence system to evaluate chemosensitivity of ovarian cancer cells by measuring their colony volume but application of this method remains in the experimental phase. Optimization of ovarian cancer treatment would improve chemotherapy results, thus increasing the overall survival, improving the quality of patient life, decreasing chemotherapy-related toxicity and resulting in economic benefits owing to better drug use.

Abstract

Individualization of treatment on the basis of in vitro chemosensitivity testing constitutes one of the aims of contemporary oncology. Although previous studies report advantages resulting from chemosensitivity laboratory tests, the issue remains an area of interest. The aim of this study was to discuss chemosensitivity assay methods of ovarian cancer cells. ATP-TCA (ATP-based tumor chemosensitivity assay) is the most investigated chemosensitivity test in ovarian cancer, with well-documented efficacy. Potentially, it is possible to use the xCELLigence system to evaluate chemosensitivity of ovarian cancer cells by measuring their colony volume but application of this method remains in the experimental phase. Optimization of ovarian cancer treatment would improve chemotherapy results, thus increasing the overall survival, improving the quality of patient life, decreasing chemotherapy-related toxicity and resulting in economic benefits owing to better drug use.
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Keywords

ovarian cancer, chemotherapy

About this article
Title

Chemosensitivity testing in ovarian cancer – prospects for the future

Journal

Ginekologia Polska

Issue

Vol 85, No 9 (2014)

DOI

10.17772/gp/1794

Bibliographic record

Ginekol Pol 2014;85(9).

Keywords

ovarian cancer
chemotherapy

Authors

Paulina Pogońska
Dariusz Wydra
Juliusz Kobierski
Anna Łojkowska
Krystyna Serkies

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