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Vol 85, No 11 (2014)
ARTICLES
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Modern diagnostics of osteoporosis based on the use of biochemical markers of bone turnover

Natalia Drwęska-Matelska, Hubert Wolski, Agnieszka Seremak-Mrozikiewicz, Marian Majchrzycki, Radosław Kujawski, Bogusław Czerny
DOI: 10.17772/gp/1913
·
Ginekol Pol 2014;85(11).

open access

Vol 85, No 11 (2014)
ARTICLES

Abstract

Osteoporosis is a disease with low bone mass and disorganization of the internal microarchitecture of bone tissue. Determination of biochemical markers allows for early diagnosis of changes in bone tissue metabolism. The search for a marker whose biological function could be directly connected with bone metabolism, clearly indicating a connection between its concentration and risk fracture as well as response to treatment, continues. Currently, measurement of collagen-derived markers of bone resorption is used in the majority of cases. They are, first of all, telopeptides of collagen type I localized on the amino end - N-terminal telopeptide of type 1 collagen (NTX), as well as on the carboxy end - C-telopeptide of type 1 collagen (CTX) of collagen molecule. Among markers of bone synthesis, special attention is paid to the procollagen type 1 carboxy-terminal propeptide (P1CP) and procollagen type 1 amino-terminal propeptide (P1NP). Simultaneous application of bone synthesis and resorption markers allows for a full imaging of the bone remodeling process and application of biochemical markers in the diagnosis and therapy of osteoporosis.

Abstract

Osteoporosis is a disease with low bone mass and disorganization of the internal microarchitecture of bone tissue. Determination of biochemical markers allows for early diagnosis of changes in bone tissue metabolism. The search for a marker whose biological function could be directly connected with bone metabolism, clearly indicating a connection between its concentration and risk fracture as well as response to treatment, continues. Currently, measurement of collagen-derived markers of bone resorption is used in the majority of cases. They are, first of all, telopeptides of collagen type I localized on the amino end - N-terminal telopeptide of type 1 collagen (NTX), as well as on the carboxy end - C-telopeptide of type 1 collagen (CTX) of collagen molecule. Among markers of bone synthesis, special attention is paid to the procollagen type 1 carboxy-terminal propeptide (P1CP) and procollagen type 1 amino-terminal propeptide (P1NP). Simultaneous application of bone synthesis and resorption markers allows for a full imaging of the bone remodeling process and application of biochemical markers in the diagnosis and therapy of osteoporosis.
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Keywords

osteoporosis / bone turnover / biochemical markers

About this article
Title

Modern diagnostics of osteoporosis based on the use of biochemical markers of bone turnover

Journal

Ginekologia Polska

Issue

Vol 85, No 11 (2014)

DOI

10.17772/gp/1913

Bibliographic record

Ginekol Pol 2014;85(11).

Keywords

osteoporosis / bone turnover / biochemical markers

Authors

Natalia Drwęska-Matelska
Hubert Wolski
Agnieszka Seremak-Mrozikiewicz
Marian Majchrzycki
Radosław Kujawski
Bogusław Czerny

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