open access

Vol 85, No 11 (2014)
ARTICLES
Get Citation

Evaluation of genomic imbalance in endometrial hyperplasia and carcinoma

Michał Bednarek, Maria Constantinou, Łukasz Kępczyński, Agata Shiar Kassassir, Anna Sobczuk, Maria Wieszczycka, Jacek Suzin, Bogdan Kałużewski
DOI: 10.17772/gp/1908
·
Ginekol Pol 2014;85(11).

open access

Vol 85, No 11 (2014)
ARTICLES

Abstract

Objective: The main goal of our study was to identify the earliest and specific genetic changes which could be associated with an increased risk of neoplastic transformation in a group of patients with endometrial hyperplasia. Another goal was to characterize genetic changes associated with advanced forms of cancer. Material and methods: The study involved forty-four (44) female patients, including five (5) patients with no histopathologically confirmed hyperplastic features, twenty-six (26) patients with histopathologically confirmed endometrial hyperplasia, and thirteen (13) patients with diagnosed carcinoma of the endometrium. The study was conducted using a custom-made 4x180K microarray of BlueGnome. Results: Copy number variations (CNV) were found in the cases without endometrial hyperplasia. Such changes occur with varying frequency in the genome of healthy female population. Significant genome imbalance was identified in the twenty-six (26) (100%) patients with diagnosed hyperplasia and in eleven (11) subjects (84.6%) with diagnosed endometrial cancer. Other, not yet reported, changes localized in characteristic regions of the genome were also found.

Abstract

Objective: The main goal of our study was to identify the earliest and specific genetic changes which could be associated with an increased risk of neoplastic transformation in a group of patients with endometrial hyperplasia. Another goal was to characterize genetic changes associated with advanced forms of cancer. Material and methods: The study involved forty-four (44) female patients, including five (5) patients with no histopathologically confirmed hyperplastic features, twenty-six (26) patients with histopathologically confirmed endometrial hyperplasia, and thirteen (13) patients with diagnosed carcinoma of the endometrium. The study was conducted using a custom-made 4x180K microarray of BlueGnome. Results: Copy number variations (CNV) were found in the cases without endometrial hyperplasia. Such changes occur with varying frequency in the genome of healthy female population. Significant genome imbalance was identified in the twenty-six (26) (100%) patients with diagnosed hyperplasia and in eleven (11) subjects (84.6%) with diagnosed endometrial cancer. Other, not yet reported, changes localized in characteristic regions of the genome were also found.
Get Citation

Keywords

endometrial hyperplasia / endometrial carcinoma / aCGH

About this article
Title

Evaluation of genomic imbalance in endometrial hyperplasia and carcinoma

Journal

Ginekologia Polska

Issue

Vol 85, No 11 (2014)

Page views

969

Article views/downloads

1534

DOI

10.17772/gp/1908

Bibliographic record

Ginekol Pol 2014;85(11).

Keywords

endometrial hyperplasia / endometrial carcinoma / aCGH

Authors

Michał Bednarek
Maria Constantinou
Łukasz Kępczyński
Agata Shiar Kassassir
Anna Sobczuk
Maria Wieszczycka
Jacek Suzin
Bogdan Kałużewski

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl