open access

Vol 85, No 12 (2014)
ARTICLES
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Does mild preeclampsia cause arterial stiffness and ventricular remodeling through inflammation?

Faika Ceylan Ciftci, Ozgur Ozgur Ciftci, Hakan Hakan Gullu, Mustafa Caliskan, Ayla Uckuyu, Ebru Emel Ozcimen
DOI: 10.17772/gp/1880
·
Ginekol Pol 2014;85(12).

open access

Vol 85, No 12 (2014)
ARTICLES

Abstract

Background: A link between preeclampsia (PE) and excessive maternal morbidity and mortality is a commonly recognized fact. Moreover, it has been suggested that chronic inflammatory state connected with PE contributes to accelerated atherosclerosis. There is also an association between PE and maternal cardiac remodeling and biventricular diastolic dysfunction. The aim of the study was to investigate the presence of impaired myocardial performance and increased arterial stiffness in patients who experienced a mild case of PE five years previously. Methods: The study included forty PE patients (40 women; mean age 33.75±7.95) and 27 healthy volunteers (27 women; mean age 36.44±10.45)Transthoracic echocardiography, including Doppler echocardiography combined with tissue Doppler imaging (TDI), and aortic stiffness index (AoSI), aortic distensibility (AoD), and aortic elastic modulus (AoEM) values were measured in each study participant. Results: There was a statistically significant increase in hsCRP, aortic stiffness index, and aortic elastic modulus in PE patients as compared to controls (2.43±1.91 vs. 3.80±2.06, p=0.007; 3.09±2.41 vs. 7.32±6.89, p=0.001; 2.89±2.11 vs. 7.00± 6.83, p=0.001), while a significant decrease was observed in the aortic strain and distensibility (respectively, 22.35±15.99 vs. 12.24±9.22, p=0.005; 11.17±9.68 vs. 6.13±4.99, p=0.018). No differences between the two groups were observed with regard to the left ventricular myocardial performance index (MPI) (0.55±0.16 vs. 0.53± 0.19, p= 0.630). Conclusions: To the best of our knowledge, this has been the first study to demonstrate impaired aortic elasticity and unaffected myocardial performance index in patients with mild PE. Moreover, these effects turned out to be significantly correlated with inflammation.

Abstract

Background: A link between preeclampsia (PE) and excessive maternal morbidity and mortality is a commonly recognized fact. Moreover, it has been suggested that chronic inflammatory state connected with PE contributes to accelerated atherosclerosis. There is also an association between PE and maternal cardiac remodeling and biventricular diastolic dysfunction. The aim of the study was to investigate the presence of impaired myocardial performance and increased arterial stiffness in patients who experienced a mild case of PE five years previously. Methods: The study included forty PE patients (40 women; mean age 33.75±7.95) and 27 healthy volunteers (27 women; mean age 36.44±10.45)Transthoracic echocardiography, including Doppler echocardiography combined with tissue Doppler imaging (TDI), and aortic stiffness index (AoSI), aortic distensibility (AoD), and aortic elastic modulus (AoEM) values were measured in each study participant. Results: There was a statistically significant increase in hsCRP, aortic stiffness index, and aortic elastic modulus in PE patients as compared to controls (2.43±1.91 vs. 3.80±2.06, p=0.007; 3.09±2.41 vs. 7.32±6.89, p=0.001; 2.89±2.11 vs. 7.00± 6.83, p=0.001), while a significant decrease was observed in the aortic strain and distensibility (respectively, 22.35±15.99 vs. 12.24±9.22, p=0.005; 11.17±9.68 vs. 6.13±4.99, p=0.018). No differences between the two groups were observed with regard to the left ventricular myocardial performance index (MPI) (0.55±0.16 vs. 0.53± 0.19, p= 0.630). Conclusions: To the best of our knowledge, this has been the first study to demonstrate impaired aortic elasticity and unaffected myocardial performance index in patients with mild PE. Moreover, these effects turned out to be significantly correlated with inflammation.
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Keywords

preeclampsia / arterial stiffness / ventricular dysfunction

About this article
Title

Does mild preeclampsia cause arterial stiffness and ventricular remodeling through inflammation?

Journal

Ginekologia Polska

Issue

Vol 85, No 12 (2014)

DOI

10.17772/gp/1880

Bibliographic record

Ginekol Pol 2014;85(12).

Keywords

preeclampsia / arterial stiffness / ventricular dysfunction

Authors

Faika Ceylan Ciftci
Ozgur Ozgur Ciftci
Hakan Hakan Gullu
Mustafa Caliskan
Ayla Uckuyu
Ebru Emel Ozcimen

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