Vol 85, No 12 (2014)
ARTICLES
Menopausal status strongly influences the utility of predictive models in differential diagnosis of ovarian tumors: An external validation of selected diagnostic tools
Rafał Moszyński, Patryk Zywica, Andrzej Wojtowicz, Sebastian Szubert, Stefan Sajdak, Anna Stachowiak, Krzysztof Dyczkowski, Maciej Wygralak, Dariusz Szpurek
DOI: 10.17772/gp/1879
·
Ginekol Pol 2014;85(12).
Vol 85, No 12 (2014)
ARTICLES
Abstract
Objectives: The aim of this study was to externally validate the diagnostic performance of the International Ovarian Tumor Analysis logistic regression models (LR1 and LR2, 2005) and other popular prognostic models including the Timmerman logistic regression model (1999), the Alcazar model (2003), the risk of malignancy index (RMI, 1990), and the risk of malignancy algorithm (ROMA, 2009). We compared these models to subjective ultrasonographic assessment performed by an experienced ultrasonography specialist, and with our previously developed scales: the sonomorphologic index and the vascularization index. Furthermore, we evaluated diagnostic tests with regard to the menopausal status of patients. Materials and methods: This study included 268 patients with adnexal masses; 167 patients with benign ovarian tumors and 101 patients with malignant ovarian tumors were enrolled. All tumors were evaluated by using transvaginal ultrasonography according to the diagnostic criteria of the nalyzed models. Materials and methods: This study included 268 patients with adnexal asses; 167 patients with benign ovarian tumors and 101 patients with malignant ovarian tumors were enrolled. All tumors were evaluated by using transvaginal ultrasonography according to the diagnostic criteria of the analyzed models. Results: The subjective ultrasonographic sessment and all of the studied predictive models achieved similar diagnostic performance in the whole study population. However, significant differences were observed when preand postmenopausal patients were analyzed separately. In the subgroup of premenopausal atients, the highest area under the curve (AUC) was achieved by subjective ultrasonographic assessment (0.931), the Alcazar model (0.912), and LR1 (0.909). Alternatively, in the group of postmenopausal patients, the highest AUC was noted for the Timmerman model (0.973), ROMA (0.951), and RMI (0.938).
Conclusions: Menopausal status is a key factor that affects the utility of prognostic models for differential diagnosis of ovarian tumors. Diagnostic models of ovarian tumors are reasonable tools for predicting tumor malignancy.
Abstract
Objectives: The aim of this study was to externally validate the diagnostic performance of the International Ovarian Tumor Analysis logistic regression models (LR1 and LR2, 2005) and other popular prognostic models including the Timmerman logistic regression model (1999), the Alcazar model (2003), the risk of malignancy index (RMI, 1990), and the risk of malignancy algorithm (ROMA, 2009). We compared these models to subjective ultrasonographic assessment performed by an experienced ultrasonography specialist, and with our previously developed scales: the sonomorphologic index and the vascularization index. Furthermore, we evaluated diagnostic tests with regard to the menopausal status of patients. Materials and methods: This study included 268 patients with adnexal masses; 167 patients with benign ovarian tumors and 101 patients with malignant ovarian tumors were enrolled. All tumors were evaluated by using transvaginal ultrasonography according to the diagnostic criteria of the nalyzed models. Materials and methods: This study included 268 patients with adnexal asses; 167 patients with benign ovarian tumors and 101 patients with malignant ovarian tumors were enrolled. All tumors were evaluated by using transvaginal ultrasonography according to the diagnostic criteria of the analyzed models. Results: The subjective ultrasonographic sessment and all of the studied predictive models achieved similar diagnostic performance in the whole study population. However, significant differences were observed when preand postmenopausal patients were analyzed separately. In the subgroup of premenopausal atients, the highest area under the curve (AUC) was achieved by subjective ultrasonographic assessment (0.931), the Alcazar model (0.912), and LR1 (0.909). Alternatively, in the group of postmenopausal patients, the highest AUC was noted for the Timmerman model (0.973), ROMA (0.951), and RMI (0.938).
Conclusions: Menopausal status is a key factor that affects the utility of prognostic models for differential diagnosis of ovarian tumors. Diagnostic models of ovarian tumors are reasonable tools for predicting tumor malignancy.
Keywords
ovarian cancer / ovarian neoplasm / ultrasonography / menopause /
/ CA125 / HE4 /
Title
Menopausal status strongly influences the utility of predictive models in differential diagnosis of ovarian tumors: An external validation of selected diagnostic tools
Journal
Ginekologia Polska
Issue
Vol 85, No 12 (2014)
Page views
1138
Article views/downloads
1146
DOI
10.17772/gp/1879
Bibliographic record
Ginekol Pol 2014;85(12).
Keywords
ovarian cancer / ovarian neoplasm / ultrasonography / menopause /
/ CA125 / HE4 /
Authors
Rafał Moszyński
Patryk Zywica
Andrzej Wojtowicz
Sebastian Szubert
Stefan Sajdak
Anna Stachowiak
Krzysztof Dyczkowski
Maciej Wygralak
Dariusz Szpurek