Vol 86, No 1 (2015)
ARTICLES
The 1691 G > A (Factor V Leiden) and 1328 T > C V Coagulation Factor polymorphisms and recurrent miscarriages
Marta Bałajewicz-Nowak, Kazimierz Pityński, Tomasz Milewicz
DOI: 10.17772/gp/1898
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Ginekol Pol 2015;86(1).
Vol 86, No 1 (2015)
ARTICLES
Abstract
Objectives. Inherited thrombophilia might lead to recurrent pregnancy loss (RPL). The aim of the study was to estimate the prevalence of V coagulation factor polymorphisms related with inherited thrombophilia among women in Malopolska region. Material and methods. Group of 136 women, who experienced at least 2 unexplained, idiopathic pregnancy loss. 106 healthy women having at least one uncomplicated pregnancy and delivered healthy children constituted a control group. Each patient were examined for factor V Leiden (FVL) and mutation 1328 T>C of factor V gene with use of real –time PCR and Taq-Man probes. Results. Among patients with RPL inhabiting region of Malopolska compared to control group occurred higher prevalence of FVL and mutation 1328 T>C. There is coincidence of polymorphism 1328 T>C of factor V gene and FVL in group of early and late RPL. Conclusions. TC genotype of 1328 T>C mutation carriers reveal tendency toward RPL below 7 weeks of pregnancy. Based on results of these findings inherited thrombophilia evaluation in patients after two or more RPL should be recommended.
Abstract
Objectives. Inherited thrombophilia might lead to recurrent pregnancy loss (RPL). The aim of the study was to estimate the prevalence of V coagulation factor polymorphisms related with inherited thrombophilia among women in Malopolska region. Material and methods. Group of 136 women, who experienced at least 2 unexplained, idiopathic pregnancy loss. 106 healthy women having at least one uncomplicated pregnancy and delivered healthy children constituted a control group. Each patient were examined for factor V Leiden (FVL) and mutation 1328 T>C of factor V gene with use of real –time PCR and Taq-Man probes. Results. Among patients with RPL inhabiting region of Malopolska compared to control group occurred higher prevalence of FVL and mutation 1328 T>C. There is coincidence of polymorphism 1328 T>C of factor V gene and FVL in group of early and late RPL. Conclusions. TC genotype of 1328 T>C mutation carriers reveal tendency toward RPL below 7 weeks of pregnancy. Based on results of these findings inherited thrombophilia evaluation in patients after two or more RPL should be recommended.
Keywords
factor Leiden / recurrent pregnancy loss / inherited thrombophilia / polymorphism 1328 T> C
Title
The 1691 G > A (Factor V Leiden) and 1328 T > C V Coagulation Factor polymorphisms and recurrent miscarriages
Journal
Ginekologia Polska
Issue
Vol 86, No 1 (2015)
Page views
946
Article views/downloads
1281
DOI
10.17772/gp/1898
Bibliographic record
Ginekol Pol 2015;86(1).
Keywords
factor Leiden / recurrent pregnancy loss / inherited thrombophilia / polymorphism 1328 T>C
Authors
Marta Bałajewicz-Nowak
Kazimierz Pityński
Tomasz Milewicz
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