open access

Vol 86, No 1 (2015)
ARTICLES
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The 1691 G > A (Factor V Leiden) and 1328 T > C V Coagulation Factor polymorphisms and recurrent miscarriages

Marta Bałajewicz-Nowak, Kazimierz Pityński, Tomasz Milewicz
DOI: 10.17772/gp/1898
·
Ginekol Pol 2015;86(1).

open access

Vol 86, No 1 (2015)
ARTICLES

Abstract

Objectives. Inherited thrombophilia might lead to recurrent pregnancy loss (RPL). The aim of the study was to estimate the prevalence of V coagulation factor polymorphisms related with inherited thrombophilia among women in Malopolska region. Material and methods. Group of 136 women, who experienced at least 2 unexplained, idiopathic pregnancy loss. 106 healthy women having at least one uncomplicated pregnancy and delivered healthy children constituted a control group. Each patient were examined for factor V Leiden (FVL) and mutation 1328 T>C of factor V gene with use of real –time PCR and Taq-Man probes. Results. Among patients with RPL inhabiting region of Malopolska compared to control group occurred higher prevalence of FVL and mutation 1328 T>C. There is coincidence of polymorphism 1328 T>C of factor V gene and FVL in group of early and late RPL. Conclusions. TC genotype of 1328 T>C mutation carriers reveal tendency toward RPL below 7 weeks of pregnancy. Based on results of these findings inherited thrombophilia evaluation in patients after two or more RPL should be recommended.

Abstract

Objectives. Inherited thrombophilia might lead to recurrent pregnancy loss (RPL). The aim of the study was to estimate the prevalence of V coagulation factor polymorphisms related with inherited thrombophilia among women in Malopolska region. Material and methods. Group of 136 women, who experienced at least 2 unexplained, idiopathic pregnancy loss. 106 healthy women having at least one uncomplicated pregnancy and delivered healthy children constituted a control group. Each patient were examined for factor V Leiden (FVL) and mutation 1328 T>C of factor V gene with use of real –time PCR and Taq-Man probes. Results. Among patients with RPL inhabiting region of Malopolska compared to control group occurred higher prevalence of FVL and mutation 1328 T>C. There is coincidence of polymorphism 1328 T>C of factor V gene and FVL in group of early and late RPL. Conclusions. TC genotype of 1328 T>C mutation carriers reveal tendency toward RPL below 7 weeks of pregnancy. Based on results of these findings inherited thrombophilia evaluation in patients after two or more RPL should be recommended.
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Keywords

factor Leiden / recurrent pregnancy loss / inherited thrombophilia / polymorphism 1328 T> C

About this article
Title

The 1691 G > A (Factor V Leiden) and 1328 T > C V Coagulation Factor polymorphisms and recurrent miscarriages

Journal

Ginekologia Polska

Issue

Vol 86, No 1 (2015)

DOI

10.17772/gp/1898

Bibliographic record

Ginekol Pol 2015;86(1).

Keywords

factor Leiden / recurrent pregnancy loss / inherited thrombophilia / polymorphism 1328 T>C

Authors

Marta Bałajewicz-Nowak
Kazimierz Pityński
Tomasz Milewicz

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