Vol 86, No 2 (2015)
ARTICLES
The role of the Fanconi anemia pathway in the pathophysiology of ovarian cancer
Agnieszka Synowiec, Jolanta Szenajch, Gabriel Wcisło, Cezary Szczylik
DOI: 10.17772/gp/2003
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Ginekol Pol 2015;86(2).
Vol 86, No 2 (2015)
ARTICLES
Abstract
We reviewed the literature on the relationship between the Fanconi anemia pathway (FA) and response to chemotherapy in patients with ovarian cancer. Despite continuous developments in medicine, ovarian cancer remains a challenge for both, physicians and researchers
seeking ways to achieve better results of chemotherapy combined with other targeted therapies. Clinically relevant resistance to chemotherapy is a major problem in treating ovarian cancer. Researchers continue to investigate mechanisms responsible for drug resistance in order to develop better therapeutic methods against ovarian cancer. Among the resistance mechanisms, defects in DNA repair, including the FA pathway, may be important in increasing the sensitivity of ovarian cancer cells to chemotherapy agents at the clinical level. A growing number of data has
shown that disruption of the FA genes may be a useful predictor of OC sensitivity to chemotherapy agents whose activity is based on DNA crosslinking mechanisms..
Abstract
We reviewed the literature on the relationship between the Fanconi anemia pathway (FA) and response to chemotherapy in patients with ovarian cancer. Despite continuous developments in medicine, ovarian cancer remains a challenge for both, physicians and researchers
seeking ways to achieve better results of chemotherapy combined with other targeted therapies. Clinically relevant resistance to chemotherapy is a major problem in treating ovarian cancer. Researchers continue to investigate mechanisms responsible for drug resistance in order to develop better therapeutic methods against ovarian cancer. Among the resistance mechanisms, defects in DNA repair, including the FA pathway, may be important in increasing the sensitivity of ovarian cancer cells to chemotherapy agents at the clinical level. A growing number of data has
shown that disruption of the FA genes may be a useful predictor of OC sensitivity to chemotherapy agents whose activity is based on DNA crosslinking mechanisms..
Keywords
ovarian cancer / Fanconi anemia pathway / cisplatin // FANCF methylation
Title
The role of the Fanconi anemia pathway in the pathophysiology of ovarian cancer
Journal
Ginekologia Polska
Issue
Vol 86, No 2 (2015)
Page views
1113
Article views/downloads
946
DOI
10.17772/gp/2003
Bibliographic record
Ginekol Pol 2015;86(2).
Keywords
ovarian cancer / Fanconi anemia pathway / cisplatin // FANCF methylation
Authors
Agnieszka Synowiec
Jolanta Szenajch
Gabriel Wcisło
Cezary Szczylik
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