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Vol 86, No 2 (2015)
ARTICLES
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The role of the Fanconi anemia pathway in the pathophysiology of ovarian cancer

Agnieszka Synowiec, Jolanta Szenajch, Gabriel Wcisło, Cezary Szczylik
DOI: 10.17772/gp/2003
·
Ginekol Pol 2015;86(2).

open access

Vol 86, No 2 (2015)
ARTICLES

Abstract

We reviewed the literature on the relationship between the Fanconi anemia pathway (FA) and response to chemotherapy in patients with ovarian cancer. Despite continuous developments in medicine, ovarian cancer remains a challenge for both, physicians and researchers seeking ways to achieve better results of chemotherapy combined with other targeted therapies. Clinically relevant resistance to chemotherapy is a major problem in treating ovarian cancer. Researchers continue to investigate mechanisms responsible for drug resistance in order to develop better therapeutic methods against ovarian cancer. Among the resistance mechanisms, defects in DNA repair, including the FA pathway, may be important in increasing the sensitivity of ovarian cancer cells to chemotherapy agents at the clinical level. A growing number of data has shown that disruption of the FA genes may be a useful predictor of OC sensitivity to chemotherapy agents whose activity is based on DNA crosslinking mechanisms..

Abstract

We reviewed the literature on the relationship between the Fanconi anemia pathway (FA) and response to chemotherapy in patients with ovarian cancer. Despite continuous developments in medicine, ovarian cancer remains a challenge for both, physicians and researchers seeking ways to achieve better results of chemotherapy combined with other targeted therapies. Clinically relevant resistance to chemotherapy is a major problem in treating ovarian cancer. Researchers continue to investigate mechanisms responsible for drug resistance in order to develop better therapeutic methods against ovarian cancer. Among the resistance mechanisms, defects in DNA repair, including the FA pathway, may be important in increasing the sensitivity of ovarian cancer cells to chemotherapy agents at the clinical level. A growing number of data has shown that disruption of the FA genes may be a useful predictor of OC sensitivity to chemotherapy agents whose activity is based on DNA crosslinking mechanisms..
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Keywords

ovarian cancer / Fanconi anemia pathway / cisplatin // FANCF methylation

About this article
Title

The role of the Fanconi anemia pathway in the pathophysiology of ovarian cancer

Journal

Ginekologia Polska

Issue

Vol 86, No 2 (2015)

DOI

10.17772/gp/2003

Bibliographic record

Ginekol Pol 2015;86(2).

Keywords

ovarian cancer / Fanconi anemia pathway / cisplatin // FANCF methylation

Authors

Agnieszka Synowiec
Jolanta Szenajch
Gabriel Wcisło
Cezary Szczylik

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