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Vol 86, No 2 (2015)
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The importance of rs1021737 and rs482843 polymorphisms of cystathionine gammalyase in the etiology of preeclampsia in the Caucasian population

Przemysław M. Mrozikiewicz, Anna Bogacz, Magdalena Omielańczyk, Hubert Wolski, Joanna Bartkowiak-Wieczorek, Edmund Grześkowiak, Bogusław Czerny, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz
DOI: 10.17772/gp/1998
·
Ginekol Pol 2015;86(2).

open access

Vol 86, No 2 (2015)
ARTICLES

Abstract

Introduction: Recently, an increasing number of reports indicate the participation of genetic factors in the pathogenesis of preeclampsia (PE). The genes involved in the synthesis of nitric oxide that participates in the vasolidation, may play an important role in the development of this disorder. Hydrogen sulfide (H2S) which is produced by cystathionine gamma-lyase exhibits a similar effect to nitric oxide. It is suggested that certain polymorphisms of the CTH gene may participate in the development of chronic hypertension and preeclampsia. Aim of the study: To evaluate the frequency of genotypes and alleles of rs1021737 and rs482843 polymorphisms of CTH gene in women with preeclampsia from Wielkopolska region. Material and methods: The study group consisted of 60 patients with diagnosed preeclampsia, into the control group 120 healthy pregnant women were enrolled. The examined rs1021737 and rs482843 polymorphisms of CTH gene were determined using PCR-RFLP method. Results: Analysis of rs482843 polymorphism in the CTH gene showed a statistically significant difference in the prevalence of mutated GG genotype (p<0.000001) and mutated G allele (p<0.000001) in the group of pregnant women with PE compared to the control group. There was no such correlation for the rs1021737 polymorphism. Furthermore, there are also no relationship between studied polymorphisms and selected clinical and biochemical parameters. Conclusions: The results of rs482843 polymorphism analysis suggest that mutated GG genotype predisposes to preeclampsia occurrence. There was no such relationship for the rs1021737 polymorphism of CTH gene. Hence, further studies based on the determination of CSE expression level in women with PE may confirm the observed relationship between the rs482843 polymorphism and the risk of preeclampsia.

Abstract

Introduction: Recently, an increasing number of reports indicate the participation of genetic factors in the pathogenesis of preeclampsia (PE). The genes involved in the synthesis of nitric oxide that participates in the vasolidation, may play an important role in the development of this disorder. Hydrogen sulfide (H2S) which is produced by cystathionine gamma-lyase exhibits a similar effect to nitric oxide. It is suggested that certain polymorphisms of the CTH gene may participate in the development of chronic hypertension and preeclampsia. Aim of the study: To evaluate the frequency of genotypes and alleles of rs1021737 and rs482843 polymorphisms of CTH gene in women with preeclampsia from Wielkopolska region. Material and methods: The study group consisted of 60 patients with diagnosed preeclampsia, into the control group 120 healthy pregnant women were enrolled. The examined rs1021737 and rs482843 polymorphisms of CTH gene were determined using PCR-RFLP method. Results: Analysis of rs482843 polymorphism in the CTH gene showed a statistically significant difference in the prevalence of mutated GG genotype (p<0.000001) and mutated G allele (p<0.000001) in the group of pregnant women with PE compared to the control group. There was no such correlation for the rs1021737 polymorphism. Furthermore, there are also no relationship between studied polymorphisms and selected clinical and biochemical parameters. Conclusions: The results of rs482843 polymorphism analysis suggest that mutated GG genotype predisposes to preeclampsia occurrence. There was no such relationship for the rs1021737 polymorphism of CTH gene. Hence, further studies based on the determination of CSE expression level in women with PE may confirm the observed relationship between the rs482843 polymorphism and the risk of preeclampsia.
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Keywords

preeclampsia / hydrogen sulfide / cystathionine gamma-lyase / genetic polymorphism

About this article
Title

The importance of rs1021737 and rs482843 polymorphisms of cystathionine gammalyase in the etiology of preeclampsia in the Caucasian population

Journal

Ginekologia Polska

Issue

Vol 86, No 2 (2015)

DOI

10.17772/gp/1998

Bibliographic record

Ginekol Pol 2015;86(2).

Keywords

preeclampsia / hydrogen sulfide / cystathionine gamma-lyase / genetic polymorphism

Authors

Przemysław M. Mrozikiewicz
Anna Bogacz
Magdalena Omielańczyk
Hubert Wolski
Joanna Bartkowiak-Wieczorek
Edmund Grześkowiak
Bogusław Czerny
Krzysztof Drews
Agnieszka Seremak-Mrozikiewicz

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