open access

Vol 86, No 2 (2015)
ARTICLES
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Comparison of carbetocin and oxytocin effectiveness for prevention of postpartum hemorrhage after caesarean delivery

Maria Brzozowska, Dawid Lisiecki, Urszula Kowalska-Koprek, Agata Karowicz-Bilińska
DOI: 10.17772/gp/1996
·
Ginekol Pol 2015;86(2).

open access

Vol 86, No 2 (2015)
ARTICLES

Abstract

Objectives: The aim of the study was to compare the effectiveness of carbetocin and oxytocin for prevention of postpartum hemorrhage (PPH) after caesarean section. Material and methods: We analyzed data from 279 patients who received 100 μg of carbetocin intravenously or 10 IU of oxytocin into the uterine muscle as a rudimentary treatment for prevention of PPH. Results: Blood loss was statistically significantly higher (p=0.0136) in the entire study group as compared to the oxytocin group, and in cases when additional uterotonics were administered (p=0.0090). Also, we observed a statistically significantly correlation between the need for additional treatment and patient BMI. Patients with prepregnancy BMI of ≥ 25 more often required additional medicaments after administration of carbetocin as compared to oxytocin (p=0.0077). We noted a statistically significantly higher rate of using additional treatment (p<0.05) after administering oxytocin into the uterine muscle as compared to intravenously given carbetocin (75% vs. 33%, respectively). Conclusions: 1. Carbetocin is more effective than oxytocin in the prevention of PPH and significantly reduces the necessity to administer therapeutic uterotonics during caesarean delivery. 2. Higher rates of additional treatment with uterotonics after the administration of carbetocin as compared to oxytocin in a group of patients after 2 or more cesarean sections and women with BMI of ≥25 require further studies in a target-selected larger sample size. 3. Based on our findings, it is not possible to conclude that 100 μg of intravenous carbetocin is more effective than 10 IU of oxytocin given to the uterine muscle during caesarean delivery to prevent PPH.

Abstract

Objectives: The aim of the study was to compare the effectiveness of carbetocin and oxytocin for prevention of postpartum hemorrhage (PPH) after caesarean section. Material and methods: We analyzed data from 279 patients who received 100 μg of carbetocin intravenously or 10 IU of oxytocin into the uterine muscle as a rudimentary treatment for prevention of PPH. Results: Blood loss was statistically significantly higher (p=0.0136) in the entire study group as compared to the oxytocin group, and in cases when additional uterotonics were administered (p=0.0090). Also, we observed a statistically significantly correlation between the need for additional treatment and patient BMI. Patients with prepregnancy BMI of ≥ 25 more often required additional medicaments after administration of carbetocin as compared to oxytocin (p=0.0077). We noted a statistically significantly higher rate of using additional treatment (p<0.05) after administering oxytocin into the uterine muscle as compared to intravenously given carbetocin (75% vs. 33%, respectively). Conclusions: 1. Carbetocin is more effective than oxytocin in the prevention of PPH and significantly reduces the necessity to administer therapeutic uterotonics during caesarean delivery. 2. Higher rates of additional treatment with uterotonics after the administration of carbetocin as compared to oxytocin in a group of patients after 2 or more cesarean sections and women with BMI of ≥25 require further studies in a target-selected larger sample size. 3. Based on our findings, it is not possible to conclude that 100 μg of intravenous carbetocin is more effective than 10 IU of oxytocin given to the uterine muscle during caesarean delivery to prevent PPH.
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Keywords

carbetocin / oxytocin / postpartum hemorrhage

About this article
Title

Comparison of carbetocin and oxytocin effectiveness for prevention of postpartum hemorrhage after caesarean delivery

Journal

Ginekologia Polska

Issue

Vol 86, No 2 (2015)

DOI

10.17772/gp/1996

Bibliographic record

Ginekol Pol 2015;86(2).

Keywords

carbetocin / oxytocin / postpartum hemorrhage

Authors

Maria Brzozowska
Dawid Lisiecki
Urszula Kowalska-Koprek
Agata Karowicz-Bilińska

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