Vol 86, No 4 (2015)
ARTICLES
The evaluation of homocysteine level in patients
with preeclampsia
Fatih Şanlıkan, Fatma Tufan, Ahmet Göçmen, Ceyda Kabadayı, Erkan Şengül
DOI: 10.17772/gp/2075
·
Ginekol Pol 2015;86(4).
Vol 86, No 4 (2015)
ARTICLES
Abstract
Objectives: The aim of the study was to evaluate the correlation between preeclampsia and blood plasma homocysteine
levels.
Material and methods: The research was conducted in a group of 114 pregnant patients who were subdivided
into three groups consisting of: 30 women with severe preeclampsia, 24 with mild preeclampsia, and 60 healthy
pregnant controls. Patient data included age, parity, body mass index (BMI), systolic and diastolic blood pressure,
homocysteine, folic acid, vitamin B12, hematocrit, hemoglobin, blood urine nitrogen, uric acid and urine analysis.
Results: There were no differences in the demographic characteristics (age, gravidity and BMI) among the groups.
Mean serum homocysteine level was significantly higher in the preeclamptic group as compared to controls (p<0.01).
Mean homocysteine level in the control group was significantly lower than in the severe and mild preeclampsia
groups, respectively (p<0.001 vs. p<0.05). There were no statistically significant differences in homocysteine levels
between mild and severe preeclampsia groups (p>0.05). Although there were statistically significant differences
among the three groups in terms of BUN, creatinine, AST, ALT, and LDH, no statistically significant differences in
serum folic acid, vitamin B12 and hemoglobin levels were found.
Conclusions: Plasma homocysteine levels are significantly elevated in patients with preeclampsia and are not
correlated with disease severity.
Abstract
Objectives: The aim of the study was to evaluate the correlation between preeclampsia and blood plasma homocysteine
levels.
Material and methods: The research was conducted in a group of 114 pregnant patients who were subdivided
into three groups consisting of: 30 women with severe preeclampsia, 24 with mild preeclampsia, and 60 healthy
pregnant controls. Patient data included age, parity, body mass index (BMI), systolic and diastolic blood pressure,
homocysteine, folic acid, vitamin B12, hematocrit, hemoglobin, blood urine nitrogen, uric acid and urine analysis.
Results: There were no differences in the demographic characteristics (age, gravidity and BMI) among the groups.
Mean serum homocysteine level was significantly higher in the preeclamptic group as compared to controls (p<0.01).
Mean homocysteine level in the control group was significantly lower than in the severe and mild preeclampsia
groups, respectively (p<0.001 vs. p<0.05). There were no statistically significant differences in homocysteine levels
between mild and severe preeclampsia groups (p>0.05). Although there were statistically significant differences
among the three groups in terms of BUN, creatinine, AST, ALT, and LDH, no statistically significant differences in
serum folic acid, vitamin B12 and hemoglobin levels were found.
Conclusions: Plasma homocysteine levels are significantly elevated in patients with preeclampsia and are not
correlated with disease severity.
Keywords
homocysteine / preeclampsia / folic acid
Title
The evaluation of homocysteine level in patients
with preeclampsia
Journal
Ginekologia Polska
Issue
Vol 86, No 4 (2015)
Page views
862
Article views/downloads
1910
DOI
10.17772/gp/2075
Bibliographic record
Ginekol Pol 2015;86(4).
Keywords
homocysteine / preeclampsia / folic acid
Authors
Fatih Şanlıkan
Fatma Tufan
Ahmet Göçmen
Ceyda Kabadayı
Erkan Şengül