Vol 86, No 4 (2015)
ARTICLES
Micrometastases in sentinel lymph node in endometrial cancer patients
Sambor Sawicki, Juliusz Kobierski, Marcin Liro, Szymon Wojtylak, Piotr Lass, Dariusz Wydra
DOI: 10.17772/gp/2071
·
Ginekol Pol 2015;86(4).
Vol 86, No 4 (2015)
ARTICLES
Abstract
Background: Detection of micrometastases in sentinel lymph nodes (SLN) extends our knowledge of lymphatic
spread in endometrial cancer, although its clinical significance has not yet been confirmed.
Objectives: The aim of study was to determine the incidence of SLN micrometastases and to analyze the association
between micrometastases and disease relapse.
Material and methods: Fifty-four patients with endometrioid endometrial cancer underwent routine surgical
therapy and sentinel lymph node biopsy (SLNB). SLNB was performed using two techniques: cervical injection
of 99mTc-labelled albumin or blue dye and fundal injection of blue dye. SLNs were subjected to ultrastaging with
immunohistochemistry (AE1/AE3, 150μm).
Results: At least one SLN was detected in 51 patients (94.4%) and bilateral SLN detection was achieved in 80.4%.
Nodal macrometastases were found in 3 patients (6.3%). SLNB enabled us to detect nodal macrometastases in
2 out of those 3 patients. In the third case, detection of SLN micrometastasis allowed to correctly determine the
nodal status, thus avoiding the false negative result of SLNB. In 48 patients with detected 184 SLNs, there were 4
patients (8.3%) with micrometastases and 4 (8.3%) with ITC foci. No significant associations between the presence
of risk factors (grade, myometrial invasion, cervical invasion, lymphovascular space invasion) and incidence of
micrometastases and/or ITC foci in SLNs were found.
Conclusions: Detection of micrometastases may result in lower false-negative rate, thus increasing SLNB safety.
Abstract
Background: Detection of micrometastases in sentinel lymph nodes (SLN) extends our knowledge of lymphatic
spread in endometrial cancer, although its clinical significance has not yet been confirmed.
Objectives: The aim of study was to determine the incidence of SLN micrometastases and to analyze the association
between micrometastases and disease relapse.
Material and methods: Fifty-four patients with endometrioid endometrial cancer underwent routine surgical
therapy and sentinel lymph node biopsy (SLNB). SLNB was performed using two techniques: cervical injection
of 99mTc-labelled albumin or blue dye and fundal injection of blue dye. SLNs were subjected to ultrastaging with
immunohistochemistry (AE1/AE3, 150μm).
Results: At least one SLN was detected in 51 patients (94.4%) and bilateral SLN detection was achieved in 80.4%.
Nodal macrometastases were found in 3 patients (6.3%). SLNB enabled us to detect nodal macrometastases in
2 out of those 3 patients. In the third case, detection of SLN micrometastasis allowed to correctly determine the
nodal status, thus avoiding the false negative result of SLNB. In 48 patients with detected 184 SLNs, there were 4
patients (8.3%) with micrometastases and 4 (8.3%) with ITC foci. No significant associations between the presence
of risk factors (grade, myometrial invasion, cervical invasion, lymphovascular space invasion) and incidence of
micrometastases and/or ITC foci in SLNs were found.
Conclusions: Detection of micrometastases may result in lower false-negative rate, thus increasing SLNB safety.
Keywords
endometrial cancer / sentinel lymph node biopsy /
/ lymph node micrometastases /
Title
Micrometastases in sentinel lymph node in endometrial cancer patients
Journal
Ginekologia Polska
Issue
Vol 86, No 4 (2015)
Page views
898
Article views/downloads
3186
DOI
10.17772/gp/2071
Bibliographic record
Ginekol Pol 2015;86(4).
Keywords
endometrial cancer / sentinel lymph node biopsy /
/ lymph node micrometastases /
Authors
Sambor Sawicki
Juliusz Kobierski
Marcin Liro
Szymon Wojtylak
Piotr Lass
Dariusz Wydra