open access

Vol 86, No 5 (2015)
ARTICLES
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First trimester biochemical markers in twin pregnancies

Şevki Çelen, Yaprak Engin-Üstün, Figen Türkçapar, Ayla Aktulay, Nafiye Yılmaz, Ayşegül Öksüzoğlu, Özlem Yörük, Nuri Danışman
DOI: 10.17772/gp/2423
·
Ginekol Pol 2015;86(5).

open access

Vol 86, No 5 (2015)
ARTICLES

Abstract

Objective: Our aim was to investigate the first trimester serum markers and nuchal translucency (NT) measurements in twin pregnancies in our population. Materials and methods: We reviewed the results of all double tests that were performed in our hospital over a three-year period. Out of them, we selected all twins and compared them with a group of three times as many singleton controls. NT measurements and the first trimester serum markers from 49 twin pregnancies were compared to those of 147 pregnant women with normal singleton pregnancy. Results: There were no statistically significant differences in age, gestational age and maternal weight between the two groups (p>0.05). We found similar NT measurements in the two groups. The median MoM of Pregnancy- Associated Plasma Protein A (PAPP-A) and fβ-hCG levels in twins were statistically significantly higher than those in singleton pregnancies. Twelve percent of the twins (12.2 %) were the result of assisted reproduction technologies. IVF versus naturally conceived pregnancies showed similar MoM of PAPP-A (2.2 vs. 1.2, respectively) and fβ-hCG (Mann-Whitney U; p = 0.195 and p = 0.958). Conclusions: Our study revealed that median PAPP-A and fβ-hCG levels for twins were less than twice those of singleton values.

Abstract

Objective: Our aim was to investigate the first trimester serum markers and nuchal translucency (NT) measurements in twin pregnancies in our population. Materials and methods: We reviewed the results of all double tests that were performed in our hospital over a three-year period. Out of them, we selected all twins and compared them with a group of three times as many singleton controls. NT measurements and the first trimester serum markers from 49 twin pregnancies were compared to those of 147 pregnant women with normal singleton pregnancy. Results: There were no statistically significant differences in age, gestational age and maternal weight between the two groups (p>0.05). We found similar NT measurements in the two groups. The median MoM of Pregnancy- Associated Plasma Protein A (PAPP-A) and fβ-hCG levels in twins were statistically significantly higher than those in singleton pregnancies. Twelve percent of the twins (12.2 %) were the result of assisted reproduction technologies. IVF versus naturally conceived pregnancies showed similar MoM of PAPP-A (2.2 vs. 1.2, respectively) and fβ-hCG (Mann-Whitney U; p = 0.195 and p = 0.958). Conclusions: Our study revealed that median PAPP-A and fβ-hCG levels for twins were less than twice those of singleton values.
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Keywords

nuchal translucency / pregnancy-associated plasma protein A / / twins / screening

About this article
Title

First trimester biochemical markers in twin pregnancies

Journal

Ginekologia Polska

Issue

Vol 86, No 5 (2015)

DOI

10.17772/gp/2423

Bibliographic record

Ginekol Pol 2015;86(5).

Keywords

nuchal translucency / pregnancy-associated plasma protein A / / twins / screening

Authors

Şevki Çelen
Yaprak Engin-Üstün
Figen Türkçapar
Ayla Aktulay
Nafiye Yılmaz
Ayşegül Öksüzoğlu
Özlem Yörük
Nuri Danışman

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