Vol 86, No 5 (2015)
ARTICLES
First trimester biochemical markers in twin pregnancies
Şevki Çelen, Yaprak Engin-Üstün, Figen Türkçapar, Ayla Aktulay, Nafiye Yılmaz, Ayşegül Öksüzoğlu, Özlem Yörük, Nuri Danışman
DOI: 10.17772/gp/2423
·
Ginekol Pol 2015;86(5).
Vol 86, No 5 (2015)
ARTICLES
Abstract
Objective: Our aim was to investigate the first trimester serum markers and nuchal translucency (NT) measurements
in twin pregnancies in our population.
Materials and methods: We reviewed the results of all double tests that were performed in our hospital over
a three-year period. Out of them, we selected all twins and compared them with a group of three times as many
singleton controls. NT measurements and the first trimester serum markers from 49 twin pregnancies were compared
to those of 147 pregnant women with normal singleton pregnancy.
Results: There were no statistically significant differences in age, gestational age and maternal weight between
the two groups (p>0.05). We found similar NT measurements in the two groups. The median MoM of Pregnancy-
Associated Plasma Protein A (PAPP-A) and fβ-hCG levels in twins were statistically significantly higher than those in
singleton pregnancies. Twelve percent of the twins (12.2 %) were the result of assisted reproduction technologies.
IVF versus naturally conceived pregnancies showed similar MoM of PAPP-A (2.2 vs. 1.2, respectively) and fβ-hCG
(Mann-Whitney U; p = 0.195 and p = 0.958).
Conclusions: Our study revealed that median PAPP-A and fβ-hCG levels for twins were less than twice those of
singleton values.
Abstract
Objective: Our aim was to investigate the first trimester serum markers and nuchal translucency (NT) measurements
in twin pregnancies in our population.
Materials and methods: We reviewed the results of all double tests that were performed in our hospital over
a three-year period. Out of them, we selected all twins and compared them with a group of three times as many
singleton controls. NT measurements and the first trimester serum markers from 49 twin pregnancies were compared
to those of 147 pregnant women with normal singleton pregnancy.
Results: There were no statistically significant differences in age, gestational age and maternal weight between
the two groups (p>0.05). We found similar NT measurements in the two groups. The median MoM of Pregnancy-
Associated Plasma Protein A (PAPP-A) and fβ-hCG levels in twins were statistically significantly higher than those in
singleton pregnancies. Twelve percent of the twins (12.2 %) were the result of assisted reproduction technologies.
IVF versus naturally conceived pregnancies showed similar MoM of PAPP-A (2.2 vs. 1.2, respectively) and fβ-hCG
(Mann-Whitney U; p = 0.195 and p = 0.958).
Conclusions: Our study revealed that median PAPP-A and fβ-hCG levels for twins were less than twice those of
singleton values.
Keywords
nuchal translucency / pregnancy-associated plasma protein A /
/ twins / screening
Title
First trimester biochemical markers in twin pregnancies
Journal
Ginekologia Polska
Issue
Vol 86, No 5 (2015)
Page views
797
Article views/downloads
2521
DOI
10.17772/gp/2423
Bibliographic record
Ginekol Pol 2015;86(5).
Keywords
nuchal translucency / pregnancy-associated plasma protein A /
/ twins / screening
Authors
Şevki Çelen
Yaprak Engin-Üstün
Figen Türkçapar
Ayla Aktulay
Nafiye Yılmaz
Ayşegül Öksüzoğlu
Özlem Yörük
Nuri Danışman
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