Vol 86, No 5 (2015)
ARTICLES
Analysis of -11391G > A and +45T > G polymorphisms of ADIPOQ gene in women with excessive weight gain during pregnancy
Hubert Wolski, Witold Kraśnik, Anna Bogacz, Joanna Bartkowiak-Wieczorek, Krzysztof Drews, Agnieszka Greber, Bogusław Czerny, Krzysztof Piątek, Agnieszka Seremak-Mrozikiewicz
DOI: 10.17772/gp/2421
·
Ginekol Pol 2015;86(5).
Vol 86, No 5 (2015)
ARTICLES
Abstract
Objectives: The aim of our study was to evaluate the frequency of genotypes and alleles of the -11391G>A and
+45T>G polymorphisms of the ADIPOQ gene in Polish women with excessive weight gain during pregnancy. A
possible correlation between these polymorphisms and selected clinical and anthropometric parameters has been
analyzed.
Material and methods: A total of 153 pregnant Caucasian women of Polish origin with normal pre-pregnancy
body mass were analyzed: 78 women with excessive weight gain (study group) and 75 women with normal weight
gain during pregnancy (control group). The analysis of the polymorphisms was performed by PCR/RFLP.
Results: The influence of the -11391G>A polymorphism on body mass and BMI values at the end of pregnancy
(p<0.05) was observed. We also detected a correlation of the +45T>G polymorphism with body mass at the end of
pregnancy and pre-pregnancy WHR values (p<0.05).
Conclusions: The observed effect of the -11391G>A polymorphism on the parameters assessed at the end of
pregnancy (BMI and body mass), suggests a protective role of the -11391A genetic variant in excessive weight
gain. It is claimed that the mutated +45G allele of the +45T>G ADIPOQ polymorphism shows a possible connection
with higher pre-pregnancy WHR values and body mass at the end of pregnancy. Our findings suggest a possible
contribution of the -11391G>A and +45T>G polymorphisms of the ADIPOQ gene to the pathomechanism of
excessive weight gain in pregnant women from the Polish population. This observation should be confirmed in a
larger sample size study.
Abstract
Objectives: The aim of our study was to evaluate the frequency of genotypes and alleles of the -11391G>A and
+45T>G polymorphisms of the ADIPOQ gene in Polish women with excessive weight gain during pregnancy. A
possible correlation between these polymorphisms and selected clinical and anthropometric parameters has been
analyzed.
Material and methods: A total of 153 pregnant Caucasian women of Polish origin with normal pre-pregnancy
body mass were analyzed: 78 women with excessive weight gain (study group) and 75 women with normal weight
gain during pregnancy (control group). The analysis of the polymorphisms was performed by PCR/RFLP.
Results: The influence of the -11391G>A polymorphism on body mass and BMI values at the end of pregnancy
(p<0.05) was observed. We also detected a correlation of the +45T>G polymorphism with body mass at the end of
pregnancy and pre-pregnancy WHR values (p<0.05).
Conclusions: The observed effect of the -11391G>A polymorphism on the parameters assessed at the end of
pregnancy (BMI and body mass), suggests a protective role of the -11391A genetic variant in excessive weight
gain. It is claimed that the mutated +45G allele of the +45T>G ADIPOQ polymorphism shows a possible connection
with higher pre-pregnancy WHR values and body mass at the end of pregnancy. Our findings suggest a possible
contribution of the -11391G>A and +45T>G polymorphisms of the ADIPOQ gene to the pathomechanism of
excessive weight gain in pregnant women from the Polish population. This observation should be confirmed in a
larger sample size study.
Keywords
excessive weight gain / genetic polymorphism / adiponectin / ADIPOQ /
Title
Analysis of -11391G>A and +45T>G polymorphisms of ADIPOQ gene in women with excessive weight gain during pregnancy
Journal
Ginekologia Polska
Issue
Vol 86, No 5 (2015)
Page views
872
Article views/downloads
913
DOI
10.17772/gp/2421
Bibliographic record
Ginekol Pol 2015;86(5).
Keywords
excessive weight gain / genetic polymorphism / adiponectin / ADIPOQ /
Authors
Hubert Wolski
Witold Kraśnik
Anna Bogacz
Joanna Bartkowiak-Wieczorek
Krzysztof Drews
Agnieszka Greber
Bogusław Czerny
Krzysztof Piątek
Agnieszka Seremak-Mrozikiewicz
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