Vol 86, No 5 (2015)
ARTICLES
Histological grading of endometrial carcinoma. Clinical and
patomorphological analysis
Sylwia Roguz, Katarzyna Wójcik-Krowiranda, Tomasz Michalski, Andrzej Bieńkiewicz
DOI: 10.17772/gp/2419
·
Ginekol Pol 2015;86(5).
Vol 86, No 5 (2015)
ARTICLES
Abstract
Objective: Retrospective clinical and pathomorphological analysis of patients undergoing surgery due to endometrial
carcinoma; analysis of the correlation between histological grading of endometrial cancer and selected
pathomorphological results.
Material and methods: Statistical analysis was based on the pathomorphological results in a group of 353 patients
operated because of endometrial carcinoma at the Clinical Department of Gynecologic Oncology, Medical
University of Lodz, between 2003 and 2013. A possible correlation between histological grading, clinical staging,
myometrial infiltration, parametrial invasion and nodal metastases to ilio-obturator lymph nodes was investigated.
Results: Among poorly differentiated carcinomas G3, myometrial infiltration above half of its thickness was observed
in 67.44% of the cases, whereas in the G2 and G1 groups it was detected in 60.82% and 39.33% of the
affected individuals, respectively. Parametrial invasion was found in 24.39% of G3 cases, i.e. 4.23 times more often
than in G2 (5.76%) and 10.65 times more often than in G1 (2.29%). Nodal metastases to ilio-obturator lymph nodes
were present in 27.50% of poorly, 10.86% of moderately, and 8.11% of well-differentiated carcinomas. Uterine appendages
were infiltrated in 23.25% of G3 cases – 3.45 times more than in G2 (6.73%) and 6.82 times more than
in G1 (3.41%).
Conclusions: Histologic grading for carcinoma at the time of diagnosis is significantly related to clinical staging.
No correlation between patient age and carcinoma grading or its clinical staging was observed. Risk of lymph node
invasion for well-differentiated carcinomas is similar to the risk for moderately differentiated carcinomas, and should
also be an indication for lymphadenectomy in that group of patients.
Abstract
Objective: Retrospective clinical and pathomorphological analysis of patients undergoing surgery due to endometrial
carcinoma; analysis of the correlation between histological grading of endometrial cancer and selected
pathomorphological results.
Material and methods: Statistical analysis was based on the pathomorphological results in a group of 353 patients
operated because of endometrial carcinoma at the Clinical Department of Gynecologic Oncology, Medical
University of Lodz, between 2003 and 2013. A possible correlation between histological grading, clinical staging,
myometrial infiltration, parametrial invasion and nodal metastases to ilio-obturator lymph nodes was investigated.
Results: Among poorly differentiated carcinomas G3, myometrial infiltration above half of its thickness was observed
in 67.44% of the cases, whereas in the G2 and G1 groups it was detected in 60.82% and 39.33% of the
affected individuals, respectively. Parametrial invasion was found in 24.39% of G3 cases, i.e. 4.23 times more often
than in G2 (5.76%) and 10.65 times more often than in G1 (2.29%). Nodal metastases to ilio-obturator lymph nodes
were present in 27.50% of poorly, 10.86% of moderately, and 8.11% of well-differentiated carcinomas. Uterine appendages
were infiltrated in 23.25% of G3 cases – 3.45 times more than in G2 (6.73%) and 6.82 times more than
in G1 (3.41%).
Conclusions: Histologic grading for carcinoma at the time of diagnosis is significantly related to clinical staging.
No correlation between patient age and carcinoma grading or its clinical staging was observed. Risk of lymph node
invasion for well-differentiated carcinomas is similar to the risk for moderately differentiated carcinomas, and should
also be an indication for lymphadenectomy in that group of patients.
Keywords
endometrial carcinoma / grading / clinical staging / nodal metastases /
Title
Histological grading of endometrial carcinoma. Clinical and
patomorphological analysis
Journal
Ginekologia Polska
Issue
Vol 86, No 5 (2015)
Page views
968
Article views/downloads
7996
DOI
10.17772/gp/2419
Bibliographic record
Ginekol Pol 2015;86(5).
Keywords
endometrial carcinoma / grading / clinical staging / nodal metastases /
Authors
Sylwia Roguz
Katarzyna Wójcik-Krowiranda
Tomasz Michalski
Andrzej Bieńkiewicz