open access

Vol 86, No 6 (2015)
ARTICLES
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The influence of intravenous ondansetron on maternal blood haemodynamics after spinal anaesthesia for caesarean section: a double-blind, placebo-controlled study

Andrzej Marciniak, Radosław Owczuk, Maria Wujtewicz, Krzysztof Preis, K. Majdyło
DOI: 10.17772/gp/2405
·
Ginekol Pol 2015;86(6).

open access

Vol 86, No 6 (2015)
ARTICLES

Abstract

Objective: verification of a hypothesis assuming that 5-HT3 receptor blockade by intravenous administration of ondansetron reduces the incidence of hypotension and bradycardia in patients undergoing spinal anaesthesia for Caesarean section. Material and methods: The study design was approved by the Bioethics Committee and included 72 patients undergoing elective Caesarean section, randomly assigned to ondansetron group (group O) or placebo group (group P). Finally, group O encompassed 35 patients administered ondansetron 8 mg i.v. dissolved in 10ml 0.9% NaCl whereas group P consisted of 34 patients receiving 0.9% NaCl 10 mg. Systolic and diastolic pressures were measured every 2 minutes since the onset of anaesthesia. Heart rate (HR) was monitored continuously. The criterion of hypotension requiring ephedrine was a decrease in systolic pressure by 20% compared to its baseline value or a decrease in systolic pressure below 90 mm Hg. The criterion of bradycardia was a decrease in HR below 60/min. Results: Hypotension was observed in 14 group O patients (39%) and in 15 group P patients (44%); the difference was not statistically significant. Bradycardia was noted in 1 group O patient (3%) and in 2 group P patients (6%); the difference was not statistically significant. Conclusion: A hypothesis assuming a reduction in pressure following subarachnoid anaesthesia for Caesarean section after the administration of 8 mg of ondansetron was not confirmed.

Abstract

Objective: verification of a hypothesis assuming that 5-HT3 receptor blockade by intravenous administration of ondansetron reduces the incidence of hypotension and bradycardia in patients undergoing spinal anaesthesia for Caesarean section. Material and methods: The study design was approved by the Bioethics Committee and included 72 patients undergoing elective Caesarean section, randomly assigned to ondansetron group (group O) or placebo group (group P). Finally, group O encompassed 35 patients administered ondansetron 8 mg i.v. dissolved in 10ml 0.9% NaCl whereas group P consisted of 34 patients receiving 0.9% NaCl 10 mg. Systolic and diastolic pressures were measured every 2 minutes since the onset of anaesthesia. Heart rate (HR) was monitored continuously. The criterion of hypotension requiring ephedrine was a decrease in systolic pressure by 20% compared to its baseline value or a decrease in systolic pressure below 90 mm Hg. The criterion of bradycardia was a decrease in HR below 60/min. Results: Hypotension was observed in 14 group O patients (39%) and in 15 group P patients (44%); the difference was not statistically significant. Bradycardia was noted in 1 group O patient (3%) and in 2 group P patients (6%); the difference was not statistically significant. Conclusion: A hypothesis assuming a reduction in pressure following subarachnoid anaesthesia for Caesarean section after the administration of 8 mg of ondansetron was not confirmed.
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Keywords

ondansetron / spinal anaesthesia / caesarean section / hypotension /

About this article
Title

The influence of intravenous ondansetron on maternal blood haemodynamics after spinal anaesthesia for caesarean section: a double-blind, placebo-controlled study

Journal

Ginekologia Polska

Issue

Vol 86, No 6 (2015)

DOI

10.17772/gp/2405

Bibliographic record

Ginekol Pol 2015;86(6).

Keywords

ondansetron / spinal anaesthesia / caesarean section / hypotension /

Authors

Andrzej Marciniak
Radosław Owczuk
Maria Wujtewicz
Krzysztof Preis
K. Majdyło

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