Vol 86, No 6 (2015)
ARTICLES
Concentration of pro-inflammatory interleukins in cervical secretions of women with PROM and in the umbilical cord blood of their newborns
DOI: 10.17772/gp/2400
Ginekol Pol 2015;86(6).
Abstract
Objectives: The aim of the study was to analyze the levels of pro-inflammatory interleukins in cervical secretions
of women with PROM, depending on Ureaplasma spp. infection and the time elapsed since the rupture of the
membranes, and to correlate their concentration in cervical secretions and in cord blood of the newborns.
Material and methods: The study included 30 women with PROM between 24 and 33+6 weeks of gestation.
Cervical swabs from women with confirmed rupture of membranes taken at certain intervals and umbilical cord
blood of their newborns constituted the study material. Cervical secretions were evaluated microbiologically and by
the PCR method. Concentrations of IL-6, IL-19, IL-10 and TNF-α were analyzed by ELISA.
Results: Ureaplasma spp. were the most frequently isolated microorganisms in cervical secretions of women with
PROM. Secretion of interleukins in the cervix was not influenced by time elapsed since the PROM.
Comparison of interleukin levels in cord blood of newborns born to mothers with and without Ureaplasma spp
infection revealed significantly higher levels of IL-6 in the case of Ureaplasma spp. A positive correlation between
IL-6 and TNF-α levels in cervical secretions and in cord blood of mothers with PROM and Ureaplasma spp. was
detected.
Conclusions:
1. Cervical culture method appears to be sufficient for detecting Ureaplasma spp.
2. Pro-inflammatory interleukins, especially IL-6, obtained by non-invasive methods can be used to predict
fetal inflammatory response.
Keywords: PROM / pro-inflammatory interleukins / cervical secretion // fetal inflammatory response syndrome /
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