Vol 86, No 6 (2015)
ARTICLES
Expression of caveolin-1 in peritumoral stroma is associated with histological grade in ovarian serous tumors
Sevil Sayhan, Gulden Diniz, Tugba Karadeniz, Duygu Ayaz, Dudu Solakoglu Kahraman, Mehmet Gokcu, Hulya Tosun Yildirim
DOI: 10.17772/gp/2398
·
Ginekol Pol 2015;86(6).
Vol 86, No 6 (2015)
ARTICLES
Abstract
Background: Previous studies have demonstrated that Caveolin-1 (Cav-1) can ambiguously behave as tumor
suppressor or tumor promoter in different neoplasms, depending on cancer type. Some findings have also revealed
that cell proliferation, migration and invasion were attenuated by the knockdown of Caveolin-1 expressions.
However, the functional and prognostic significance of Caveolin-1 in most tumors remains to be fully elucidated.
Objectives: The aim of the study was to investigate a possible association between tissue Caveolin-1 expression
and the clinicopathologic features of ovarian serous tumors.
Material and methods: Caveolin-1 expression was studied in a total of 82 formalin-fixed, paraffin-embedded
specimens of ovarian serous tumors and its association with different clinicopathologic parameters was evaluated.
Results: The study included 36 (43.9%) benign, 12 (14.6%) borderline and 34 (41.5%) malignant serous tumors.
Mean patient age was 43.9±14.4 years (17-72 years). Statistical analysis revealed that if the tumor becomes more
aggressive and invasive, it losses the stromal Caveolin-1 expression (p=0.001). Also, parallel changes between
stromal and perivascular Caveolin-1 expressions were observed.
Conclusions: Our findings demonstrated a link between Caveolin-1 expression and the aggressiveness of ovarian
cancer. Therefore, it seems safe to suggest that Cav-1 may act as a differential diagnostic biomarker in ovarian
serous tumors.
Abstract
Background: Previous studies have demonstrated that Caveolin-1 (Cav-1) can ambiguously behave as tumor
suppressor or tumor promoter in different neoplasms, depending on cancer type. Some findings have also revealed
that cell proliferation, migration and invasion were attenuated by the knockdown of Caveolin-1 expressions.
However, the functional and prognostic significance of Caveolin-1 in most tumors remains to be fully elucidated.
Objectives: The aim of the study was to investigate a possible association between tissue Caveolin-1 expression
and the clinicopathologic features of ovarian serous tumors.
Material and methods: Caveolin-1 expression was studied in a total of 82 formalin-fixed, paraffin-embedded
specimens of ovarian serous tumors and its association with different clinicopathologic parameters was evaluated.
Results: The study included 36 (43.9%) benign, 12 (14.6%) borderline and 34 (41.5%) malignant serous tumors.
Mean patient age was 43.9±14.4 years (17-72 years). Statistical analysis revealed that if the tumor becomes more
aggressive and invasive, it losses the stromal Caveolin-1 expression (p=0.001). Also, parallel changes between
stromal and perivascular Caveolin-1 expressions were observed.
Conclusions: Our findings demonstrated a link between Caveolin-1 expression and the aggressiveness of ovarian
cancer. Therefore, it seems safe to suggest that Cav-1 may act as a differential diagnostic biomarker in ovarian
serous tumors.
Keywords
Caveolin-1 / serous tumors / ovary /
Title
Expression of caveolin-1 in peritumoral stroma is associated with histological grade in ovarian serous tumors
Journal
Ginekologia Polska
Issue
Vol 86, No 6 (2015)
Page views
1146
Article views/downloads
1010
DOI
10.17772/gp/2398
Bibliographic record
Ginekol Pol 2015;86(6).
Keywords
Caveolin-1 / serous tumors / ovary /
Authors
Sevil Sayhan
Gulden Diniz
Tugba Karadeniz
Duygu Ayaz
Dudu Solakoglu Kahraman
Mehmet Gokcu
Hulya Tosun Yildirim
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