open access

Vol 86, No 7 (2015)
ARTICLES
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Endometriosis and carcinosarcoma – a hypothetical correlation or a proven pathogenetic pathway? Colon carcinosarcoma with origin in endometriotic foci – a case report

Maria Szubert, Jacek Suzin, Paweł Stawerski, Katarzyna Kowalczyk-Amico, Markus Duechler
DOI: 10.17772/gp/58638
·
Ginekol Pol 2015;86(7).

open access

Vol 86, No 7 (2015)
ARTICLES

Abstract

We present the first case of a patient with a synchronic occurrence of three neoplasms: non-small cell lung cancer, serous cancer of the ovary, and carcinosarcoma of the colon. Moreover, the possible origin of the carcinosarcoma is an endometriotic focus, which is an extremely rare occurrence, especially in women with no history of endometriotic treatment. Immunohistochemical staining of the carcinosarcoma was positive for CD10, estrogen receptors and desmin – typical markers for endometriotic foci. The growth of endometriosis depends on estrogen, which is produced at reduced levels after menopause. However, in some cases endometriosis could be diagnosed de novo in postmenopausal women. On the basis of the reported patient we discuss possible correlations between endometriosis and carcinosarcoma, as well as treatment methods of carcinosarcoma.

Abstract

We present the first case of a patient with a synchronic occurrence of three neoplasms: non-small cell lung cancer, serous cancer of the ovary, and carcinosarcoma of the colon. Moreover, the possible origin of the carcinosarcoma is an endometriotic focus, which is an extremely rare occurrence, especially in women with no history of endometriotic treatment. Immunohistochemical staining of the carcinosarcoma was positive for CD10, estrogen receptors and desmin – typical markers for endometriotic foci. The growth of endometriosis depends on estrogen, which is produced at reduced levels after menopause. However, in some cases endometriosis could be diagnosed de novo in postmenopausal women. On the basis of the reported patient we discuss possible correlations between endometriosis and carcinosarcoma, as well as treatment methods of carcinosarcoma.
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Keywords

endometriosis / carcinosarcoma / ovarian adenocarcinoma

About this article
Title

Endometriosis and carcinosarcoma – a hypothetical correlation or a proven pathogenetic pathway? Colon carcinosarcoma with origin in endometriotic foci – a case report

Journal

Ginekologia Polska

Issue

Vol 86, No 7 (2015)

DOI

10.17772/gp/58638

Bibliographic record

Ginekol Pol 2015;86(7).

Keywords

endometriosis / carcinosarcoma / ovarian adenocarcinoma

Authors

Maria Szubert
Jacek Suzin
Paweł Stawerski
Katarzyna Kowalczyk-Amico
Markus Duechler

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