open access

Vol 86, No 8 (2015)
ARTICLES
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Fetal programming and etiology of osteoporosis

Wojciech Pieńkowski, Hubert Wolski, Krzysztof Drews, Agnieszka Seremak-Mrozikiewicz
DOI: 10.17772/gp/58795
·
Ginekol Pol 2015;86(8).

open access

Vol 86, No 8 (2015)
ARTICLES

Abstract

Osteoporosis is a multifactorial skeletal disorder characterized by low bone mass and microarchitectural deterioration of bone tissue, resulting in increased risk of fracture. Peak bone mass is an important predictor of later risk of osteoporosis. Epidemiological studies revealed that the risk of osteoporosis might be modified by exposure to environmental factors during intrauterine life and early postnatal period. This review summarizes the influence of fetal programming on the development of osteoporosis based on the epidemiological studies and potential mechanisms of epigenetic regulation of gene expression.

Abstract

Osteoporosis is a multifactorial skeletal disorder characterized by low bone mass and microarchitectural deterioration of bone tissue, resulting in increased risk of fracture. Peak bone mass is an important predictor of later risk of osteoporosis. Epidemiological studies revealed that the risk of osteoporosis might be modified by exposure to environmental factors during intrauterine life and early postnatal period. This review summarizes the influence of fetal programming on the development of osteoporosis based on the epidemiological studies and potential mechanisms of epigenetic regulation of gene expression.
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Keywords

osteoporosis, fetal programming, epidemiological studies, epigenetic regulation

About this article
Title

Fetal programming and etiology of osteoporosis

Journal

Ginekologia Polska

Issue

Vol 86, No 8 (2015)

DOI

10.17772/gp/58795

Bibliographic record

Ginekol Pol 2015;86(8).

Keywords

osteoporosis
fetal programming
epidemiological studies
epigenetic regulation

Authors

Wojciech Pieńkowski
Hubert Wolski
Krzysztof Drews
Agnieszka Seremak-Mrozikiewicz

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