open access

Vol 86, No 9 (2015)
ARTICLES
Get Citation

DRD1 and DRD4 dopamine receptors in the etiology of preeclampsia

Hubert Wolski, Paulina Marek, Krzysztof Drews, Magdalena Barlik, Grażyna Kurzawińska, Marcin Ożarowski, Bogusław Czerny, Agnieszka Seremak-Mrozikiewicz
DOI: 10.17772/gp/59240
·
Ginekol Pol 2015;86(9).

open access

Vol 86, No 9 (2015)
ARTICLES

Abstract

Introduction: Recent reports have suggested an association between genetic polymorphisms of dopamine receptors and the development of an increased risk of chronic hypertension, as well as preeclampsia (PE). Objectives: The aim of the study was to evaluate the impact of the -48A>G DRD1 and -521C>T DRD4 polymorphisms in the etiology of PE among Polish women. Material and methods: Ninety-eight preeclamptic women and 120 healthy pregnant controls were enrolled in the study. The investigated polymorphisms of the DRD1 and DRD4 genes were identified using PCR/RFLP methods. Results: As far as the -48A>G DRD1 polymorphism is concerned, the mutated -48GG genotype was more often found in controls (14.2% ) than in the PE group (10.2%, ns), and the subgroup with severe PE (8.2%). Also, the frequency of the mutated -48G allele was higher in controls (39.6%) than in the PE group (33.2%, ns), and in the subgroup with severe PE (31.6%, ns). As for the -521C>T DRD4 polymorphism, a similar occurrence of the mutated -521TT genotype and the -521T allele in all of the investigate groups was observed. Lower serum concentrations of total protein (5.59 g/L and 5.57 g/L vs. 6.17 g/L in carriers of the -521CC genotype, p=0.02) were noted in patients with the mutated homozygous -521TT genotype and heterozygous -521CT genotype of DRD4. Conclusions: The obtained results suggest a possible protective role of the mutated -48G DRD1 allele in the etiology of preeclampsia, especially its severe form. The presence of the mutated -521T DRD4 allele could influence the decrease of total blood protein in preeclamptic patients. The observed frequency of dopamine DRD1 and DRD4 polymorphisms is similar to the distribution of these variants in other Caucasian populations.

Abstract

Introduction: Recent reports have suggested an association between genetic polymorphisms of dopamine receptors and the development of an increased risk of chronic hypertension, as well as preeclampsia (PE). Objectives: The aim of the study was to evaluate the impact of the -48A>G DRD1 and -521C>T DRD4 polymorphisms in the etiology of PE among Polish women. Material and methods: Ninety-eight preeclamptic women and 120 healthy pregnant controls were enrolled in the study. The investigated polymorphisms of the DRD1 and DRD4 genes were identified using PCR/RFLP methods. Results: As far as the -48A>G DRD1 polymorphism is concerned, the mutated -48GG genotype was more often found in controls (14.2% ) than in the PE group (10.2%, ns), and the subgroup with severe PE (8.2%). Also, the frequency of the mutated -48G allele was higher in controls (39.6%) than in the PE group (33.2%, ns), and in the subgroup with severe PE (31.6%, ns). As for the -521C>T DRD4 polymorphism, a similar occurrence of the mutated -521TT genotype and the -521T allele in all of the investigate groups was observed. Lower serum concentrations of total protein (5.59 g/L and 5.57 g/L vs. 6.17 g/L in carriers of the -521CC genotype, p=0.02) were noted in patients with the mutated homozygous -521TT genotype and heterozygous -521CT genotype of DRD4. Conclusions: The obtained results suggest a possible protective role of the mutated -48G DRD1 allele in the etiology of preeclampsia, especially its severe form. The presence of the mutated -521T DRD4 allele could influence the decrease of total blood protein in preeclamptic patients. The observed frequency of dopamine DRD1 and DRD4 polymorphisms is similar to the distribution of these variants in other Caucasian populations.
Get Citation

Keywords

dopamine receptor DRD1 / dopamine receptor DRD4 / preeclampsia /, / genetic polymorphism /

About this article
Title

DRD1 and DRD4 dopamine receptors in the etiology of preeclampsia

Journal

Ginekologia Polska

Issue

Vol 86, No 9 (2015)

DOI

10.17772/gp/59240

Bibliographic record

Ginekol Pol 2015;86(9).

Keywords

dopamine receptor DRD1 / dopamine receptor DRD4 / preeclampsia /
/ genetic polymorphism /

Authors

Hubert Wolski
Paulina Marek
Krzysztof Drews
Magdalena Barlik
Grażyna Kurzawińska
Marcin Ożarowski
Bogusław Czerny
Agnieszka Seremak-Mrozikiewicz

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl