open access

Vol 86, No 10 (2015)
ARTICLES
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Intraperitoneal invasiveness of ovarian cancer from the cellular and molecular perspective

Patrycja Sosińska, Justyna Mikuła-Pietrasik, Angelika Kuczmarska, Krzysztof Książek
DOI: 10.17772/gp/58751
·
Ginekol Pol 2015;86(10).

open access

Vol 86, No 10 (2015)
ARTICLES

Abstract

Peritoneal cavity is the primary site of ovarian cancer metastasis. It is believed that the intraperitoneal invasiveness of the malignancy is determined by interactions between cancer cells and the normal peritoneal mesothelium. The nature of these interactions is, however, unclear, which is the reason of divergent opinions about the role of mesothelial cells in the progression of the disease. According to some authors, the mesothelium acts as a barrier that prevents the expansion of the tumor cells. According to others, however, these cells actively promote various elements of cancer cell invasiveness. The aim of this study was to present the Reader both the concepts on the role of mesothelial cells in the intraperitoneal development of ovarian cancer metastasis, with particular emphasis on mechanisms of reciprocal interaction between the normal and the cancer cells.

Abstract

Peritoneal cavity is the primary site of ovarian cancer metastasis. It is believed that the intraperitoneal invasiveness of the malignancy is determined by interactions between cancer cells and the normal peritoneal mesothelium. The nature of these interactions is, however, unclear, which is the reason of divergent opinions about the role of mesothelial cells in the progression of the disease. According to some authors, the mesothelium acts as a barrier that prevents the expansion of the tumor cells. According to others, however, these cells actively promote various elements of cancer cell invasiveness. The aim of this study was to present the Reader both the concepts on the role of mesothelial cells in the intraperitoneal development of ovarian cancer metastasis, with particular emphasis on mechanisms of reciprocal interaction between the normal and the cancer cells.
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Keywords

ovarian cancer, cancer metastasis, mesothelial cells, peritoneal cavity

About this article
Title

Intraperitoneal invasiveness of ovarian cancer from the cellular and molecular perspective

Journal

Ginekologia Polska

Issue

Vol 86, No 10 (2015)

DOI

10.17772/gp/58751

Bibliographic record

Ginekol Pol 2015;86(10).

Keywords

ovarian cancer
cancer metastasis
mesothelial cells
peritoneal cavity

Authors

Patrycja Sosińska
Justyna Mikuła-Pietrasik
Angelika Kuczmarska
Krzysztof Książek

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