The role of miRNA in endometrial cancer - with special consideration of miRNA 205.

Abstract

MiRNAs are small non-coding molecules of ribonucleic acids of approximately 22 bp length that serve as regulators of gene expression and protein translation due to interference with messenger RNA (mRNA). MiRNAs, that take part in the regulation of cell cycle and apoptosis, may be associated with carcinogenesis. Aberrant expression of miRNAs in endometrial cancer might contribute to the endometrial cancer initiation or progression, metastasis formation and influence cancer invasiveness. Specific miRNAs expressed in endometrial cancer tissues may serve as diagnostic markers of the disease, prognostic biomarkers or play an important part in oncological therapy. We aimed to describe the role of miRNAs in endometrial cancer, with special consideration of miRNA 205.