open access

Vol 87, No 1 (2016)
Review paper
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hCG – related molecules and their measurement

Anna Szczerba, Piotr Białas, Paweł Piotr Pięta, Anna Jankowska
DOI: 10.17772/gp/60981
·
Pubmed: 27306471
·
Ginekol Pol 2016;87(1):65-70.

open access

Vol 87, No 1 (2016)
REVIEW PAPERS Obstetrics

Abstract

Measurements of human chorionic gonadotropin (hCG) synthesized by trophoblast cells is a powerful tool of pregnancy monitoring. It was showed that similarly to pregnancy also trophoblastic and nontrophoblastic malignancies produce variety of hCG molecules. In urine and serum of both pregnant women and tumors patients a fifteen various forms of hCG, such as: regular hCG, hyperglycosylated hCG and predominant hyperglycosylated hCG free β, were identified. These forms might be useful in order to recognize between physiological and pathological pregnancies as well as cancers. Even the presence of these different hormone variants is well documented the commercially available biochemical tests detecting hCG failed to identified and distinguish among these forms. Especially hard is to identify glycan chains linked to heterodimer. Thus, a detailed analysis of hCG-related molecules produced during physiological and pathological condition, together with a new tests development are needed.

Abstract

Measurements of human chorionic gonadotropin (hCG) synthesized by trophoblast cells is a powerful tool of pregnancy monitoring. It was showed that similarly to pregnancy also trophoblastic and nontrophoblastic malignancies produce variety of hCG molecules. In urine and serum of both pregnant women and tumors patients a fifteen various forms of hCG, such as: regular hCG, hyperglycosylated hCG and predominant hyperglycosylated hCG free β, were identified. These forms might be useful in order to recognize between physiological and pathological pregnancies as well as cancers. Even the presence of these different hormone variants is well documented the commercially available biochemical tests detecting hCG failed to identified and distinguish among these forms. Especially hard is to identify glycan chains linked to heterodimer. Thus, a detailed analysis of hCG-related molecules produced during physiological and pathological condition, together with a new tests development are needed.
Get Citation

Keywords

Chorionic Gonadotropin, hCG, hCGβ, H-hCG, hCG assays

About this article
Title

hCG – related molecules and their measurement

Journal

Ginekologia Polska

Issue

Vol 87, No 1 (2016)

Article type

Review paper

Pages

65-70

DOI

10.17772/gp/60981

Pubmed

27306471

Bibliographic record

Ginekol Pol 2016;87(1):65-70.

Keywords

Chorionic Gonadotropin
hCG
hCGβ
H-hCG
hCG assays

Authors

Anna Szczerba
Piotr Białas
Paweł Piotr Pięta
Anna Jankowska

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