open access

Vol 87, No 3 (2016)
Research paper
Published online: 2016-04-13
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Umbilical markers of perinatal hypoxia

Małgorzata Fiala, Małgorzata Baumert, Piotr Surmiak, Zofia Walencka, Patrycja Sodowska
DOI: 10.17772/gp/60552
·
Pubmed: 27306129
·
Ginekol Pol 2016;87(3):200-204.

open access

Vol 87, No 3 (2016)
ORIGINAL PAPERS Obstetrics
Published online: 2016-04-13

Abstract

Objectives: The aim of the study was to evaluate activin A and NGAL levels as potential early markers of perinatal hypoxia.

Material and methods: We prospectively studied 58 full-term newborns: 24 with perinatal hypoxia (study group) and 34 healthy controls. Umbilical cord blood samples were obtained from all subjects immediately after delivery for the measurement of activin A and NGAL levels. Both biomarkers were correlated with biochemical indicators od hypoxia and neonatal complications.

Results: Activin A levels were significantly higher in hypoxic as compared to non-hypoxic newborns (0.51 vs. 0.22pg/mL; p<0.01). NGAL levels were also higher in asphyxiated babies as compared to controls (99.1 vs. 22.3ng/mL; p<0.001). A correlation between NGAL and activin A levels was detected (R=0.54; p<0.01). NGAL concentration was also correlated with Apgar score at 5 min. and pH value, HCO3, based deficit and lactate levels. ROC curve analysis demonstrated the cutoff value of >33.9ng/ml for NGAL in prediction of perinatal asphyxia in neonates, with a sensitivity of 100% and specificity 78.3%, whereas the cutoff value for activin A was 0.208ng/ml had, with a sensitivity of 93.1% and only 26.7% specificity.

Conclusions: Asphyxiated neonates demonstrate elevated NGAL and activin A levels as compared to controls. The correlation of NGAL with clinical and biochemical signs of neonatal hypoxia, as well as higher sensitivity and specificity for NGAL measurements, have led us to believe that NGAL could be a better marker of perinatal hypoxia than activin A.  

Abstract

Objectives: The aim of the study was to evaluate activin A and NGAL levels as potential early markers of perinatal hypoxia.

Material and methods: We prospectively studied 58 full-term newborns: 24 with perinatal hypoxia (study group) and 34 healthy controls. Umbilical cord blood samples were obtained from all subjects immediately after delivery for the measurement of activin A and NGAL levels. Both biomarkers were correlated with biochemical indicators od hypoxia and neonatal complications.

Results: Activin A levels were significantly higher in hypoxic as compared to non-hypoxic newborns (0.51 vs. 0.22pg/mL; p<0.01). NGAL levels were also higher in asphyxiated babies as compared to controls (99.1 vs. 22.3ng/mL; p<0.001). A correlation between NGAL and activin A levels was detected (R=0.54; p<0.01). NGAL concentration was also correlated with Apgar score at 5 min. and pH value, HCO3, based deficit and lactate levels. ROC curve analysis demonstrated the cutoff value of >33.9ng/ml for NGAL in prediction of perinatal asphyxia in neonates, with a sensitivity of 100% and specificity 78.3%, whereas the cutoff value for activin A was 0.208ng/ml had, with a sensitivity of 93.1% and only 26.7% specificity.

Conclusions: Asphyxiated neonates demonstrate elevated NGAL and activin A levels as compared to controls. The correlation of NGAL with clinical and biochemical signs of neonatal hypoxia, as well as higher sensitivity and specificity for NGAL measurements, have led us to believe that NGAL could be a better marker of perinatal hypoxia than activin A.  

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About this article
Title

Umbilical markers of perinatal hypoxia

Journal

Ginekologia Polska

Issue

Vol 87, No 3 (2016)

Article type

Research paper

Pages

200-204

Published online

2016-04-13

DOI

10.17772/gp/60552

Pubmed

27306129

Bibliographic record

Ginekol Pol 2016;87(3):200-204.

Authors

Małgorzata Fiala
Małgorzata Baumert
Piotr Surmiak
Zofia Walencka
Patrycja Sodowska

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