open access

Vol 87, No 3 (2016)
Research paper
Published online: 2016-04-13
Get Citation

Multiple multiparity is a negative prognostic factor for endometrial cancer in Poland

Anna o Abacjew-Chmyłk, Łukasz Chmyłko, Dariusz Grzegorz Wydra, Hanna Olszewska, Paulina Kobiela, Katarzyna Ciach
DOI: 10.17772/gp/60071
·
Pubmed: 27306125
·
Ginekol Pol 2016;87(3):178-182.

open access

Vol 87, No 3 (2016)
ORIGINAL PAPERS Gynecology
Published online: 2016-04-13

Abstract

Background: Nulliparity is one of the most important reproductive risk factors for endometrial cancer. It is still discussed whether multiparity implies a more favorable course of the disease and higher overall survival rates. The aim of the study was to analyze the effect of parity on the overall survival of endometrial cancer patients in Poland.

Material and method: A retrospective analysis of parity on survival rates was performed in 810 women treated surgically for endometrial cancer in a single referential center of gynecological oncology.

Results: Higher parity was shown to be associated with significantly lower survival rates (p=0.03). Parity turned out to be an independent prognostic factor of survival (HR 1.9). Multiple multiparous women were older at the time of surgery, more often presented with deep myometrial infiltration and with involvement of the cervical stroma and had higher clinical stages of the cancer (only according to FIGO 1988 classification). The group of multiple multiparous women was characterized by significantly lower recurrence rates. Multiple multiparous women significantly more often presented with lower educational level, more often were diagnosed with comorbidities and a history of other malignancies, while breast cancer and colon cancer were of lesser evidence in multiple multiparous endometrial cancer patients.

Conclusion: Multiparity turns out to be an unfavorable prognostic factor of survival in Polish women. Unfavorable prognosis in endometrial cancer patients in this group is associated with interactions between risk factors and negative prognostic factors, i.e. the conditions of tumor growth, rather than with the nulliparity itself.  

Abstract

Background: Nulliparity is one of the most important reproductive risk factors for endometrial cancer. It is still discussed whether multiparity implies a more favorable course of the disease and higher overall survival rates. The aim of the study was to analyze the effect of parity on the overall survival of endometrial cancer patients in Poland.

Material and method: A retrospective analysis of parity on survival rates was performed in 810 women treated surgically for endometrial cancer in a single referential center of gynecological oncology.

Results: Higher parity was shown to be associated with significantly lower survival rates (p=0.03). Parity turned out to be an independent prognostic factor of survival (HR 1.9). Multiple multiparous women were older at the time of surgery, more often presented with deep myometrial infiltration and with involvement of the cervical stroma and had higher clinical stages of the cancer (only according to FIGO 1988 classification). The group of multiple multiparous women was characterized by significantly lower recurrence rates. Multiple multiparous women significantly more often presented with lower educational level, more often were diagnosed with comorbidities and a history of other malignancies, while breast cancer and colon cancer were of lesser evidence in multiple multiparous endometrial cancer patients.

Conclusion: Multiparity turns out to be an unfavorable prognostic factor of survival in Polish women. Unfavorable prognosis in endometrial cancer patients in this group is associated with interactions between risk factors and negative prognostic factors, i.e. the conditions of tumor growth, rather than with the nulliparity itself.  

Get Citation
About this article
Title

Multiple multiparity is a negative prognostic factor for endometrial cancer in Poland

Journal

Ginekologia Polska

Issue

Vol 87, No 3 (2016)

Article type

Research paper

Pages

178-182

Published online

2016-04-13

DOI

10.17772/gp/60071

Pubmed

27306125

Bibliographic record

Ginekol Pol 2016;87(3):178-182.

Authors

Anna o Abacjew-Chmyłk
Łukasz Chmyłko
Dariusz Grzegorz Wydra
Hanna Olszewska
Paulina Kobiela
Katarzyna Ciach

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk
tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl