open access

Vol 87, No 3 (2016)
Research paper
Published online: 2016-04-13
Get Citation

Expression of VEGF isoforms and their receptors in uterine myomas

Danuta Plewka, Michał Morek, Edyta Bogunia, Józef Waloszek, Andrzej Plewka
DOI: 10.17772/gp/60979
·
Pubmed: 27306124
·
Ginekol Pol 2016;87(3):166-177.

open access

Vol 87, No 3 (2016)
ORIGINAL PAPERS Gynecology
Published online: 2016-04-13

Abstract

Objectives: The aim of the study was to determine the expression of VEGF (vascular endothelial growth factor) isoforms and their receptors in uterine myomas.

Material and methods: The study included 40 women with myomas of reproductive age and 40 perimenopausal women (the study group). Myometrial samples (the control group) were taken from 10 women undergoing hysterectomy for ovarian tumors and 10 older women undergoing hysterectomy for uterine prolapse.

Results: A significantly increased expression of VEGF-A has been found in myomas, both small and large, in the younger women, which may by a sign of increased angiogenesis and intensive tumor growth. In perimenopausal women, the increase of VEGF expression was observed only in the endothelium and vascular smooth muscle.

Conclusion: An important conclusion of this study is that angiogenesis is independent of myoma size, which may suggest intensive tumor growth and the related increased angiogenesis. High expression of VEGF-A and VEGF-R1 receptors in large myomas can probably cause malignant transformation and more extensive growth, regardless of patient age.

Abstract

Objectives: The aim of the study was to determine the expression of VEGF (vascular endothelial growth factor) isoforms and their receptors in uterine myomas.

Material and methods: The study included 40 women with myomas of reproductive age and 40 perimenopausal women (the study group). Myometrial samples (the control group) were taken from 10 women undergoing hysterectomy for ovarian tumors and 10 older women undergoing hysterectomy for uterine prolapse.

Results: A significantly increased expression of VEGF-A has been found in myomas, both small and large, in the younger women, which may by a sign of increased angiogenesis and intensive tumor growth. In perimenopausal women, the increase of VEGF expression was observed only in the endothelium and vascular smooth muscle.

Conclusion: An important conclusion of this study is that angiogenesis is independent of myoma size, which may suggest intensive tumor growth and the related increased angiogenesis. High expression of VEGF-A and VEGF-R1 receptors in large myomas can probably cause malignant transformation and more extensive growth, regardless of patient age.

Get Citation
About this article
Title

Expression of VEGF isoforms and their receptors in uterine myomas

Journal

Ginekologia Polska

Issue

Vol 87, No 3 (2016)

Article type

Research paper

Pages

166-177

Published online

2016-04-13

DOI

10.17772/gp/60979

Pubmed

27306124

Bibliographic record

Ginekol Pol 2016;87(3):166-177.

Authors

Danuta Plewka
Michał Morek
Edyta Bogunia
Józef Waloszek
Andrzej Plewka

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