Severe novel coronavirus infection in late pregnancy: a case report
Abstract
This study reported the diagnosis, treatment and perinatal outcome of a novel coronavirus infection patient at 29+6 weeks pregnancy. The patient case came to the hospital with persistent fever and cough for 6 days. Patient's chest CT diagnosis showed double pneumonia, and viral infection was considered. Blood gas analysis revealed type I respiratory failure, and a throat swab nucleic acid test confirmed the novel coronavirus infection (critical type). After 13 days of isolation and supportive treatment, the patient recovered and was discharged from hospital after two consecutive negative nucleic acid tests. After discharge, the patient delivered a baby girl successfully by cesarean section on March 16, 2023. The newborn weighing 2050 g, with an Apgar score of 9–10 points /1–5 minutes. The newborn was transferred to the neonatology department for hospitalization and discharged 10 days later. The patient and her baby were followed up for nearly 1 year. Both mother and daughter were in good health.
Keywords: severe type of novel coronavirus infectionpregnancyviruspneumoniainfantfollow-up visit
References
- Röbl-Mathieu M, Kunstein A, Liese J, et al. Vaccination in Pregnancy. Dtsch Arztebl Int. 2021; 118(15): 262–268.
- Albrecht M, Arck PC. Vertically Transferred Immunity in Neonates: Mothers, Mechanisms and Mediators. Front Immunol. 2020; 11: 555.
- Khan L. Immunization Considerations in Pregnancy. Pediatr Ann. 2019; 48(7): e251–e254.
- Lim WS, Macfarlane JT, Colthorpe CL, et al. Pneumonia and pregnancy. Thorax. 2001; 56(5): 398–405.
- Goodnight WH, Soper DE. Pneumonia in pregnancy. Crit Care Med. 2005; 33(10 Suppl): S390–S397.
- Goodrum LA. Pneumonia in pregnancy. Semin Perinatol. 1997; 21(4): 276–283.
- Laibl VR, Sheffield JS. Influenza and pneumonia in pregnancy. Clin Perinatol. 2005; 32(3): 727–738.
- Pearlstein T. Depression during Pregnancy. Best Pract Res Clin Obstet Gynaecol. 2015; 29(5): 754–764.
- Van den Bergh BRH, van den Heuvel MI, Lahti M, et al. Prenatal developmental origins of behavior and mental health: The influence of maternal stress in pregnancy. Neurosci Biobehav Rev. 2020; 117: 26–64.
- Collier ARY, McMahan K, Yu J, et al. Immunogenicity of COVID-19 mRNA Vaccines in Pregnant and Lactating Women. JAMA. 2021; 325(23): 2370–2380.
- Nunes MC, Madhi SA. COVID-19 vaccines in pregnancy. Trends Mol Med. 2022; 28(8): 662–680.
- Wainstock T, Yoles I, Sergienko R, et al. Prenatal maternal COVID-19 vaccination and pregnancy outcomes. Vaccine. 2021; 39(41): 6037–6040.
- Moro F, Buonsenso D, Moruzzi MC, et al. How to perform lung ultrasound in pregnant women with suspected COVID-19. Ultrasound Obstet Gynecol. 2020; 55(5): 593–598.
- Safiabadi Tali SH, LeBlanc JJ, Sadiq Z, et al. Tools and Techniques for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)/COVID-19 Detection. Clin Microbiol Rev. 2021; 34(3).
- Habas K, Nganwuchu C, Shahzad F, et al. Resolution of coronavirus disease 2019 (COVID-19). Expert Rev Anti Infect Ther. 2020; 18(12): 1201–1211.
- Majumder J, Minko T. Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19. AAPS J. 2021; 23(1): 14.
- Zambrano LD, Ellington S, Strid P, et al. CDC COVID-19 Response Pregnancy and Infant Linked Outcomes Team. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020; 69(44): 1641–1647.
- Filchakova O, Dossym D, Ilyas A, et al. Review of COVID-19 testing and diagnostic methods. Talanta. 2022; 244: 123409.
- Erenler AK, Baydin A. Challenges in COVID-19 diagnosis. Bratisl Lek Listy. 2020; 121(12): 864.
- Juan J, Gil MM, Rong Z, et al. Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol. 2020; 56(1): 15–27.
- Vidal MJ, Martínez-Solanas È, Mendoza S, et al. Impact of SARS-CoV-2 infection in pregnant women and their babies: clinical and epidemiological features. Gac Sanit. 2023; 37: 102332.
- von Delft A, Hall MD, Kwong AD, et al. Accelerating antiviral drug discovery: lessons from COVID-19. Nat Rev Drug Discov. 2023; 22(7): 585–603.
- Yuan Y, Jiao B, Qu L, et al. The development of COVID-19 treatment. Front Immunol. 2023; 14: 1125246.
- Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7). Chin Med J (Engl). 2020; 133(9): 1087–1095.
- Jum'ah H, Kundrapu S, Jabri A, et al. Cardiac macrophage density in Covid-19 infection: relationship to myocyte necrosis and acute lung injury. Cardiovasc Pathol. 2022; 60: 107447.
- Swenson KE, Swenson ER, Swenson KE, et al. The Pathophysiology and Dangers of Silent Hypoxemia in COVID-19 Lung Injury. Ann Am Thorac Soc. 2021; 18(7): 1098–1105.
- Aabakke AJM, Petersen TG, Wøjdemann K, et al. Risk factors for and pregnancy outcomes after SARS-CoV-2 in pregnancy according to disease severity: A nationwide cohort study with validation of the SARS-CoV-2 diagnosis. Acta Obstet Gynecol Scand. 2023; 102(3): 282–293.
- Verma K, Prasad DN, Kumar B, et al. Brain and COVID-19 Crosstalk: Pathophysiological and Psychological Manifestations. ACS Chem Neurosci. 2020; 11(20): 3194–3203.
- Masood S. What We Do Not Know about COVID-19. .
- Kołomańska D, Zarawski M, Mazur-Bialy A. Physical Activity and Depressive Disorders in Pregnant Women-A Systematic Review. Medicina (Kaunas). 2019; 55(5).
- Keskin DD, Keskin S, Bostan S. Mental disorders among pregnant women during the COVID-19 pandemic. A cross-sectional study. Sao Paulo Med J. 2022; 140(1): 87–93.
- Gimbel LA, Allshouse AA, Neff D, et al. Mental health symptom changes in pregnant individuals across the COVID-19 pandemic: a prospective longitudinal study. BMC Pregnancy Childbirth. 2022; 22(1): 897.