Tom 9, Nr 2 (2017)
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Opublikowany online: 2017-12-29

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Zapobieganie ostremu zapaleniu trzustki w czasie cholangiopankreatografii wstecznej ― czy już wszystko jasne?

Michał Lipiński
Gastroenterologia Kliniczna 2017;9(2):33-39.

Streszczenie

Ostre zapalenie trzustki jest najczęstszym powikłaniem cholangiopankreatografii wstecznej występującym u 2–15% wszystkich pacjentów poddawanych tej procedurze. W artykule omówiono postępowanie farmakologiczne, techniki związane z cholangiopankreatografią wsteczną stosowane w celu  zredukowania ryzyka jatrogennego ostrego zapalenia trzustki oraz czynniki ryzyka związane z tym powikłaniem. Mechanizmy prowadzące do uszkodzeń tkanek w ostrym zapaleniu trzustki po cholangiopankreatografii wstecznej  stanowią kolejne etapy ewolucji procesu zapalnego  i  mogą potencjalnie stać się celem terapii prewencyjnej. Chociaż stosowanie  w badaniach klinicznych wielu cząsteczek wiązało się ze zmniejszeniem ryzyka ostrego zapalenia trzustki po cholangiopankreatografii wstecznej tylko niektóre z nich mają udowodnione działanie w dużych, randomizowanych badaniach. Stosowanie niesteroidowych leków przeciwazaplnych podawanych doodbytniczo należy do potwierdzonych metod prewencji ostrego zapalenie trzustki po cholangiopankreatografii wstecznej. W artykule podjęto próbę określenia i oceny znanych metod stosowanych w celu redukcji ryzyka jatrogennego ostrego zapalenia trzustki.

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