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Relapsing polychondritis
Affiliations- Katedra i Klinika Chorób Wewnętrznych, Reumatologii i Immunologii Klinicznej Śląskiego Uniwersytetu Medycznego w Katowicach, Ziołowa 45/47, 40-635 Katowice, Poland
open access
Abstract
Relapsing polychondritis (RP) is a rare autoimmune disease with recurrent episodes of inflammation of cartilage of the auricular pinna, nose, larynx, trachea and bronchi, as well as involvement of the inner ear, eye, heart, large vessels, kidneys and skin. Clinical presentation is heterogeneous and diagnostics may be difficult. Therapy includes application of glucocorticoids, immunosuppressants, biologics (tocilizumab and TNF-alpha antagonists). Relapsing polychondritis may lead to a life-threatening damage and obturation of the airways as well as valvular defects and aortic aneurysms.
Abstract
Relapsing polychondritis (RP) is a rare autoimmune disease with recurrent episodes of inflammation of cartilage of the auricular pinna, nose, larynx, trachea and bronchi, as well as involvement of the inner ear, eye, heart, large vessels, kidneys and skin. Clinical presentation is heterogeneous and diagnostics may be difficult. Therapy includes application of glucocorticoids, immunosuppressants, biologics (tocilizumab and TNF-alpha antagonists). Relapsing polychondritis may lead to a life-threatening damage and obturation of the airways as well as valvular defects and aortic aneurysms.
Keywords
cartilage — inflammation; auricular pinna inflammation; obturation of the respiratory tract
About this articleTitle
Relapsing polychondritis
Journal
Issue
Article type
Review paper
Pages
10-16
Published online
2020-07-01
Page views
846
Article views/downloads
378
DOI
Bibliographic record
Forum Reumatol 2020;6(1):10-16.
Keywords
cartilage — inflammation
auricular pinna inflammation
obturation of the respiratory tract
Authors
Sonia Kostarczyk-Rogacz
Eugeniusz Józef Kucharz
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