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Bullous pemphigoid in a young patient with coexisting long-standing psoriasis, successfully treated with methotrexate
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Affiliations- Department of Dermatology, Venerology and Allergology, Medical University of Gdansk, Poland
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Abstract
Introduction: Bullous pemphigoid is an autoimmune bullous disease, affecting elderly people, most often in the 8th decade of life. The article aims to present a rare case of bullous pemphigoid manifested at an atypically young age, occurred with long-standing psoriasis and was successfully treated with methotrexate.
Case report: A 40-year-old male presented to the department with the presence of bullous lesions on the limbs and trunk, together with psoriatic papules and plaques in the lumbar region and lower limbs, stating the history of psoriasis. Based on clinical, direct immunofluorescence and serological findings, bullous pemphigoid was diagnosed. For the treatment methotrexate and topical clobetasol propionate cream were used with a good clinical response after 4 weeks.
Discussion: The coexistence of psoriasis and bullous pemphigoid is not common and poses a therapeutic challenge. Methotrexate can be a good treatment option for these patients. Future research is needed to explain the pathogenic mechanism of bullous pemphigoid and psoriasis coexistence.
Abstract
Introduction: Bullous pemphigoid is an autoimmune bullous disease, affecting elderly people, most often in the 8th decade of life. The article aims to present a rare case of bullous pemphigoid manifested at an atypically young age, occurred with long-standing psoriasis and was successfully treated with methotrexate.
Case report: A 40-year-old male presented to the department with the presence of bullous lesions on the limbs and trunk, together with psoriatic papules and plaques in the lumbar region and lower limbs, stating the history of psoriasis. Based on clinical, direct immunofluorescence and serological findings, bullous pemphigoid was diagnosed. For the treatment methotrexate and topical clobetasol propionate cream were used with a good clinical response after 4 weeks.
Discussion: The coexistence of psoriasis and bullous pemphigoid is not common and poses a therapeutic challenge. Methotrexate can be a good treatment option for these patients. Future research is needed to explain the pathogenic mechanism of bullous pemphigoid and psoriasis coexistence.
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Keywords
bullous pemphigoid, psoriasis, methotrexate
About this articleTitle
Bullous pemphigoid in a young patient with coexisting long-standing psoriasis, successfully treated with methotrexate
Journal
Issue
Article type
Case report
Pages
75-77
Published online
2023-03-02
Page views
2241
Article views/downloads
43
DOI
Bibliographic record
Forum Dermatologicum 2023;9(2):75-77.
Keywords
bullous pemphigoid
psoriasis
methotrexate
Authors
Aleksandra Rudnikowicz
Damian Kadylak
Izabela Błażewicz
Adrian Karamon
Roman Nowicki
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