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Phototoxic cutaneous reaction after sodium diclofenac use
Affiliations- Klinika i Zakład Dermatologii, Instytut Nauk Medycznych, Kolegium Nauk Medycznych Uniwersytetu Rzeszowskiego
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Abstract
Multifaceted effects and easy availability of non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a higher likelihood of skin adverse side effects including photoallergic and phototoxic reactions. Their frequency increases significantly in the spring-summer period due to increased exposure to UV radiation. Here, we present a 52-year-old patient who applied 1% sodium diclofenac due to pain in the upper limb, and then underwent intensive exposure to solar radiation. On the second day, she developed swelling, erythema, increased soreness and bullous lesions filled with serous content. On the second day, systemic symptoms occurred: chills, fever, headache. Based on
the whole disease picture, a phototoxic reaction induced by NSAIDs was diagnosed. In the treatment, glucocorticoids were used generally and topically, obtaining a significant improvement in the clinical condition.
Abstract
Multifaceted effects and easy availability of non-steroidal anti-inflammatory drugs (NSAIDs) are associated with a higher likelihood of skin adverse side effects including photoallergic and phototoxic reactions. Their frequency increases significantly in the spring-summer period due to increased exposure to UV radiation. Here, we present a 52-year-old patient who applied 1% sodium diclofenac due to pain in the upper limb, and then underwent intensive exposure to solar radiation. On the second day, she developed swelling, erythema, increased soreness and bullous lesions filled with serous content. On the second day, systemic symptoms occurred: chills, fever, headache. Based on
the whole disease picture, a phototoxic reaction induced by NSAIDs was diagnosed. In the treatment, glucocorticoids were used generally and topically, obtaining a significant improvement in the clinical condition.
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Keywords
phototoxicity, photoallergy, topical NSAIDs, UV radiation, adverse effect
About this articleTitle
Phototoxic cutaneous reaction after sodium diclofenac use
Journal
Issue
Article type
Case report
Pages
146-148
Published online
2022-09-06
Page views
671
Article views/downloads
24
DOI
Bibliographic record
Forum Dermatologicum 2022;8(3):146-148.
Keywords
phototoxicity
photoallergy
topical NSAIDs
UV radiation
adverse effect
Authors
Kinga Kołcz
Dominik Samotij
Adam Reich
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