Vol 9, No 1 (2023)
Case report
Published online: 2022-09-02
Get Citation

Telogen effluvium as a manifestation of SARS-CoV-2 infection

Julia Alicja Lewandowska1, Natalia Joanna Machoń1, Aleksandra Znajewska-Pander2, Agnieszka Owczarczyk-Saczonek3, Waldemar Placek3
·
Forum Dermatologicum 2023;9(1):32-36.
Affiliations
  1. Studenckie Koło Naukowe Dermatologiczno-Wenerologiczne Uniwersytetu Warmińsko-Mazurskiego w Olsztynie
  2. Katedra Dermatologii, Chorób Przenoszonych Drogą Płciową i Immunologii Klinicznej, Uniwersytet Warmińsko-Mazurski w Olsztynie
  3. Klinika i Katedra Dermatologii, Chorób Przenoszonych Drogą Płciową i Immunologii Klinicznej, Uniwersytet Warmińsko-Mazurski w Olsztynie

paid access

Vol 9, No 1 (2023)
CASE STUDY
Published online: 2022-09-02

Abstract

We describe the case of a 44-year-old female patient, who presented to a dermatologist with increased hair loss 5 months after COVID-19 and one month after the second immunization with Pfizer and BioNTech Comirnaty vaccine. The purpose of this study is to demonstrate the importance of SARS-CoV-2 virus infection in the pathogenesis and treatment planning of telogenetic alopecia based on a medical case. The transition of the hair cycle from anagen to telogen phase is shortened under the influence of COVID-19 (to an average of about 50 days) and additionally this period is shorter as compared to classical telogenetic alopecia, in which the transition is usually observed after 3–4 months. The cause of excessive hair loss may be cytokine storm activation, vitamin and mineral deficiency, immune response and stress. Treatment targeting the factors involved in etiopathogenesis should therefore be implemented. The topic of complications following SARS-CoV-2 virus infection is particularly timely. There are many scientific studies addressing the aspect of post-infection complications. However, these are mainly preliminary observations. This article points out the need for a study of post-COVID-19 alopecia on a large group of people, as too late diagnosis of excessive hair loss, or lack thereof, can cause irreversible consequences (significant hair thinning and even complete baldness).

Abstract

We describe the case of a 44-year-old female patient, who presented to a dermatologist with increased hair loss 5 months after COVID-19 and one month after the second immunization with Pfizer and BioNTech Comirnaty vaccine. The purpose of this study is to demonstrate the importance of SARS-CoV-2 virus infection in the pathogenesis and treatment planning of telogenetic alopecia based on a medical case. The transition of the hair cycle from anagen to telogen phase is shortened under the influence of COVID-19 (to an average of about 50 days) and additionally this period is shorter as compared to classical telogenetic alopecia, in which the transition is usually observed after 3–4 months. The cause of excessive hair loss may be cytokine storm activation, vitamin and mineral deficiency, immune response and stress. Treatment targeting the factors involved in etiopathogenesis should therefore be implemented. The topic of complications following SARS-CoV-2 virus infection is particularly timely. There are many scientific studies addressing the aspect of post-infection complications. However, these are mainly preliminary observations. This article points out the need for a study of post-COVID-19 alopecia on a large group of people, as too late diagnosis of excessive hair loss, or lack thereof, can cause irreversible consequences (significant hair thinning and even complete baldness).

Get Citation

Keywords

COVID-19, SARS-CoV-2, telogen effluvium, hair loss

About this article
Title

Telogen effluvium as a manifestation of SARS-CoV-2 infection

Journal

Forum Dermatologicum

Issue

Vol 9, No 1 (2023)

Article type

Case report

Pages

32-36

Published online

2022-09-02

Page views

672

Article views/downloads

33

DOI

10.5603/FD.a2022.0025

Bibliographic record

Forum Dermatologicum 2023;9(1):32-36.

Keywords

COVID-19
SARS-CoV-2
telogen effluvium
hair loss

Authors

Julia Alicja Lewandowska
Natalia Joanna Machoń
Aleksandra Znajewska-Pander
Agnieszka Owczarczyk-Saczonek
Waldemar Placek

References (16)
  1. Rossi A, Magri F, Sernicola A, et al. Telogen effluvium after sars-cov-2 infection: a series of cases and possible pathogenetic mechanisms. Skin Appendage Disord. 2021; 21: 1–5.
  2. Starace M, Iorizzo M, Sechi A, et al. Trichodynia and telogen effluvium in COVID-19 patients: Results of an international expert opinion survey on diagnosis and management. JAAD Int. 2021; 5: 11–18.
  3. Moreno‐Arrones OM, Lobato‐Berezo A, Gomez‐Zubiaur A, et al. SARS-CoV-2-induced telogen effluvium: a multicentric study . J Eur Acad Dermatol Venereol. 2021; 35(3): e181–e183.
  4. Costela-Ruiz VJ, Illescas-Montes R, Puerta-Puerta JM, et al. SARS-CoV-2 infection: The role of cytokines in COVID-19 disease. Cytokine Growth Factor Rev. 2020; 54: 62–75.
  5. Tosti A, Misciali C, Bardazzi F, et al. Telogen effluvium due to recombinant interferon alpha-2b. Dermatology. 1992; 184(2): 124–125.
  6. Kwack MiH, Ahn JiS, Kim MK, et al. Dihydrotestosterone-inducible IL-6 inhibits elongation of human hair shafts by suppressing matrix cell proliferation and promotes regression of hair follicles in mice. J Invest Dermatol. 2012; 132(1): 43–49.
  7. Mandt N, Geilen CC, Wrobel A, et al. Interleukin-4 induces apoptosis in cultured human follicular keratinocytes, but not in dermal papilla cells. Eur J Dermatol. 2002; 12(5): 432–438.
  8. Xiong Y, Harmon CS. Interleukin-1beta is differentially expressed by human dermal papilla cells in response to PKC activation and is a potent inhibitor of human hair follicle growth in organ culture. J Interferon Cytokine Res. 1997; 17(3): 151–157.
  9. Hadshiew IM, Foitzik K, Arck PC, et al. Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. J Invest Dermatol. 2004; 123(3): 455–457.
  10. Cheung EJ, Sink JR, English Iii JC. Vitamin and mineral deficiencies in patients with telogen effluvium: a retrospective cross-sectional study. J Drugs Dermatol. 2016; 15(10): 1235–1237.
  11. Jothimani D, Kailasam E, Danielraj S, et al. COVID-19: Poor outcomes in patients with zinc deficiency. Int J Infect Dis. 2020; 100: 343–349.
  12. Demir M, Demir F, Aygun H. Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease. J Med Virol. 2021; 93(5): 2992–2999.
  13. Chéret J, Bertolini M, Ponce L, et al. Olfactory receptor OR2AT4 regulates human hair growth. Nat Commun. 2018; 9(1): 3624.
  14. Piccolo D, Crisman G, Conforti C, et al. Trichobiolight: A new, effective protocol in the treatment of androgenetic alopecia and telogen effluvium. Dermatol Ther. 2021; 34(2): e14799.
  15. Petrov A, Vasileva M. Effect of platelet-rich plasma on diffuse effluvium in post-COVID-19 infection. Our Derm Online. 2021: 267–269.
  16. Nguyen B, Tosti A. Alopecia in patients with COVID-19: A systematic review and meta-analysis. JAAD Int. 2022; 7: 67–77.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By VM Media Group sp. z o.o., ul. Świętokrzyska 73, 80–180 Gdańsk, Poland
phone: +48 58 320 94 94, fax: +48 58 320 94 60, e-mail: viamedica@viamedica.pl