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Vol 7, No 2 (2021)
Review paper
Published online: 2021-06-16
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Extramammary Paget’s disease: the utility of photodynamic therapy

Ewelina Mazur1, Robert Kijowski2, Adam Reich12
DOI: 10.5603/FD.a2021.0008
·
Forum Dermatologicum 2021;7(2):50-55.
Affiliations
  1. Zakład Dermatologii, Instytut Nauk Medycznych, Kolegium Nauk Medycznych Uniwersytetu Rzeszowskiego
  2. Klinika Dermatologii, Kliniczny Szpital Wojewódzki nr 1 w Rzeszowie

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Vol 7, No 2 (2021)
REVIEW ARTICLES
Published online: 2021-06-16

Abstract

Extramammary Paget’s disease (EMPD) is a rare intraepithelial neoplasm which accounts for about 1% of malignant tumors in the anogenital region. It is often multifocal. Clinically it presents as a delineated erythematous plaque with typical white scales and erosions. Due to the non-specific clinical picture, the EMPD should always be considered as the differential diagnosis of pruritic lesions located in areas rich in apocrine glands and resistant to topical therapy. The golden standard in the EMPD treatment is the complete removal of the lesion with a safety margin. However, in patients with large tumors, when the surgical intervention would be mutilating for the patient, photodynamic therapy, especially in combination with imiquimod, is a good alternative and improves the patient’s quality of life.

Abstract

Extramammary Paget’s disease (EMPD) is a rare intraepithelial neoplasm which accounts for about 1% of malignant tumors in the anogenital region. It is often multifocal. Clinically it presents as a delineated erythematous plaque with typical white scales and erosions. Due to the non-specific clinical picture, the EMPD should always be considered as the differential diagnosis of pruritic lesions located in areas rich in apocrine glands and resistant to topical therapy. The golden standard in the EMPD treatment is the complete removal of the lesion with a safety margin. However, in patients with large tumors, when the surgical intervention would be mutilating for the patient, photodynamic therapy, especially in combination with imiquimod, is a good alternative and improves the patient’s quality of life.

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Keywords

Paget’s disease; adenocarcinoma; photodynamic therapy; imiquimod

About this article
Title

Extramammary Paget’s disease: the utility of photodynamic therapy

Journal

Forum Dermatologicum

Issue

Vol 7, No 2 (2021)

Article type

Review paper

Pages

50-55

Published online

2021-06-16

Page views

831

Article views/downloads

45

DOI

10.5603/FD.a2021.0008

Bibliographic record

Forum Dermatologicum 2021;7(2):50-55.

Keywords

Paget’s disease
adenocarcinoma
photodynamic therapy
imiquimod

Authors

Ewelina Mazur
Robert Kijowski
Adam Reich

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