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Pathergy phenomenon leading to the diagnosis of pyoderma gangrenosum
, 2, 2, 3, 2
Affiliations- Students’ Scientific Circle of Experimental Dermatology, Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University
- Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University
- Department of Pathology, Institute of Medical Sciences, Medical College of Rzeszow University
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Abstract
Pyoderma gangrenosum (PG) is a rare skin disease of chronic course and a tendency for recurrence. Pathergy phenomenon, which is characterized by the rapid development of skin lesions at the site of a mechanical trauma, affects about 30% of patients with PG. However, this symptom is not pathognomonic for PG and may develop in other conditions including Behçet’s disease, Sweet syndrome and Crohn’s disease. In the current paper, we present a 25-year-old woman with an infiltrative lesion with a tendency for ulceration located in the interscapular region. Excision of the skin lesion led to the development of infiltration with small ulcerations at the site of surgical intervention. Clinical presentation corresponded to the classical pathergic reaction, which in turn raised the suspicion of PG. Therapy consisted of cyclosporin 5 mg/kg/day and topical ointment with 0.05% of betamethasone and 0.1% of gentamicin. Complete healing was observed after three weeks of treatment. We present the case in order to draw attention to the diagnostic significance of pathergy phenomenon in dermatology.
Abstract
Pyoderma gangrenosum (PG) is a rare skin disease of chronic course and a tendency for recurrence. Pathergy phenomenon, which is characterized by the rapid development of skin lesions at the site of a mechanical trauma, affects about 30% of patients with PG. However, this symptom is not pathognomonic for PG and may develop in other conditions including Behçet’s disease, Sweet syndrome and Crohn’s disease. In the current paper, we present a 25-year-old woman with an infiltrative lesion with a tendency for ulceration located in the interscapular region. Excision of the skin lesion led to the development of infiltration with small ulcerations at the site of surgical intervention. Clinical presentation corresponded to the classical pathergic reaction, which in turn raised the suspicion of PG. Therapy consisted of cyclosporin 5 mg/kg/day and topical ointment with 0.05% of betamethasone and 0.1% of gentamicin. Complete healing was observed after three weeks of treatment. We present the case in order to draw attention to the diagnostic significance of pathergy phenomenon in dermatology.
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Keywords
pathergy; pyoderma gangrenosum; Behçet’s disease; needle prick test
About this articleTitle
Pathergy phenomenon leading to the diagnosis of pyoderma gangrenosum
Journal
Issue
Article type
Case report
Pages
12-16
Published online
2021-03-17
Page views
633
Article views/downloads
43
DOI
Bibliographic record
Forum Dermatologicum 2021;7(1):12-16.
Keywords
pathergy
pyoderma gangrenosum
Behçet’s disease
needle prick test
Authors
Agata Ossolińska
Natalia Morawiecka
Magdalena Żychowska
Aleksandra Opalińska
Elżbieta Ostańska
Adam Reich
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