open access
Graham-Little Syndrome — a rare entity of both scarring and non-scarring alopecia concomitance
open access
Abstract
Graham Little-Piccardi-Lassueur syndrome also called in a shorter form as Graham-Little syndrome, is a rare clinical entity characterized by the symptomatic triad including multifocal progressive cicatricial alopecia on the scalp, non-scarring hair loss of axillae and pubic areas and presence of keratosis pilaris-like eruption on the trunk and extremities. The etiology of the disease remains unknown with some hypotheses proposed. The condition is diagnosed based on clinical presentation, trichoscopical characteristic findings and histopathological analysis. The treatment of the syndrome is challenging. The therapeutic strategy includes topical or systemic corticosteroids, retinoids and PUVA therapy with different efficacy. We present the case of this rare syndrome and discuss it from the practical point of view in terms of diagnosis and treatment approach.
Abstract
Graham Little-Piccardi-Lassueur syndrome also called in a shorter form as Graham-Little syndrome, is a rare clinical entity characterized by the symptomatic triad including multifocal progressive cicatricial alopecia on the scalp, non-scarring hair loss of axillae and pubic areas and presence of keratosis pilaris-like eruption on the trunk and extremities. The etiology of the disease remains unknown with some hypotheses proposed. The condition is diagnosed based on clinical presentation, trichoscopical characteristic findings and histopathological analysis. The treatment of the syndrome is challenging. The therapeutic strategy includes topical or systemic corticosteroids, retinoids and PUVA therapy with different efficacy. We present the case of this rare syndrome and discuss it from the practical point of view in terms of diagnosis and treatment approach.
Keywords
lichen planopilaris; alopecia; Graham-Little syndrome
About this articleTitle
Graham-Little Syndrome — a rare entity of both scarring and non-scarring alopecia concomitance
Journal
Issue
Article type
Case report
Pages
6-10
Published online
2019-02-20
Page views
445
Article views/downloads
1571
DOI
10.5603/FD.2019.0002
Bibliographic record
Forum Dermatologicum 2019;5(1):6-10.
Keywords
lichen planopilaris
alopecia
Graham-Little syndrome
Authors
Magdalena Radziszewska
Adriana Rakowska
Lidia Rudnicka
Joanna Czuwara
