Vol 10, No 2 (2024)
Research paper
Published online: 2024-05-08

open access

Page views 163
Article views/downloads 104
Get Citation

Connect on Social Media

Connect on Social Media

Study of the effect of probiotics on the therapeutic effect obtained in the reduction of allergic symptoms in patients diagnosed with atopic dermatitis

Paula Banderowicz1, Natalia Wierzbowska1, Andrzej Pawlik1
Forum Dermatologicum 2024;10(2):35-41.

Abstract

Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin disease posing a significant burden on healthcare resources and patients’ quality of life. It is a complex disease with a wide spectrum of clinical presentations and combinations of symptoms. Atopic dermatitis affects up to 20% of children and up to 3% of adults. Recent data show that its prevalence is still increasing, especially in low-income countries. This study aimed to check whether the use of probiotic therapy affects the reduction of allergic symptoms in patients diagnosed with AD.

Material and methods: Questionnaires of 70 respondents diagnosed with AD who took a probiotic for at least 5 days were analysed. To conduct the study, an anonymous, original survey was used in the form of a form created on Google Drive consisting of 19 questions with the possibility of answering both single and multiple choice and with the possibility of providing your own answer.

Results: The most beneficial strains affecting the reduction of allergic symptoms are bacteria of the genus Lactobacillus. The average duration of use of probiotic therapy to reduce allergic symptoms is from 2 weeks to 3 months.

Conclusions: The study showed that the implementation of probiotic therapy shortens the duration of therapy for AD and reduces allergic symptoms such as redness, itching of the skin and allergic rhinitis co-occurring in patients with AD.

Article available in PDF format

View PDF Download PDF file

References

  1. Abuabara K, Margolis DJ, Langan SM. The long-term course of atopic dermatitis. Dermatol Clin. 2017; 35(3): 291–297.
  2. Thomsen SF. Epidemiology and natural history of atopic diseases. Eur Clin Respir J. 2015; 2(1): 24642.
  3. Maldonado Galdeano C, Cazorla SI, Lemme Dumit JM, et al. Beneficial effects of probiotic consumption on the immune system. Ann Nutr Metab. 2019; 74(2): 115–124.
  4. Lolou V, Panayiotidis M. Functional role of probiotics and prebiotics on skin health and disease. Fermentation. 2019; 5(2): 41.
  5. Cristofori F, Dargenio VN, Dargenio C, et al. Anti-Inflammatory and immunomodulatory effects of probiotics in gut inflammation: a door to the body. Front Immunol. 2021; 12: 578386.
  6. Frazier W, Bhardwaj N. Atopic dermatitis: diagnosis and treatment. Am Fam Physician. 2020; 101(10): 590–598.
  7. Lee JiH, Son SW, Cho SH. A comprehensive review of the treatment of atopic eczema. Allergy Asthma Immunol Res. 2016; 8(3): 181–190.
  8. Fanfaret IS, Boda D, Ion LM, et al. Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review). Exp Ther Med. 2021; 22(6): 1376.
  9. Mastrandrea F, Coradduzza G, Serio G, et al. Probiotics reduce the CD34+ hemopoietic precursor cell increased traffic in allergic subjects. Eur Ann Allergy Clin Immunol. 2004; 36(4): 118–122.
  10. Gerasimov SV, Vasjuta VV, Myhovych OO, et al. Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. Am J Clin Dermatol. 2010; 11(5): 351–361.
  11. Roży A, Jaguś P, Chorostowska-Wynimko J. [Probiotics in the prevention and treatment of allergic diseases]. Pneumonol Alergol Pol. 2012; 80(1): 65–76.
  12. Hoang Ba, Shaw G, Pham P, et al. Lactobacillus rhamnosus cell lysate in the management of resistant childhood atopic eczema. Inflamm Allergy Drug Targets. 2010; 9(3): 192–196.
  13. Majamaa H, Isolauri E. Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol. 1997; 99(2): 179–185.
  14. Rosenfeldt V, Benfeldt E, Nielsen SD, et al. Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol. 2003; 111(2): 389–395.
  15. Pessi T, Sütas Y, Hurme M, et al. Interleukin-10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clin Exp Allergy. 2000; 30(12): 1804–1808.
  16. Michelotti A, Cestone E, De Ponti I, et al. Efficacy of a probiotic supplement in patients with atopic dermatitis: a randomized, double-blind, placebo-controlled clinical trial. Eur J Dermatol. 2021; 31(2): 225–232.
  17. Kim SO, Ah YM, Yu YMi, et al. Effects of probiotics for the treatment of atopic dermatitis: a meta-analysis of randomized controlled trials. Ann Allergy Asthma Immunol. 2014; 113(2): 217–226.
  18. Wickens K, Stanley TV, Mitchell EA, et al. Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also reduce atopic sensitization? Clin Exp Allergy. 2013; 43(9): 1048–1057.
  19. Wu YJ, Wu WF, Hung CW, et al. Evaluation of efficacy and safety of Lactobacillus rhamnosus in children aged 4-48 months with atopic dermatitis: An 8-week, double-blind, randomized, placebo-controlled study. J Microbiol Immunol Infect. 2017; 50(5): 684–692.