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Trichilemmal carcinoma of the groin area of unknown primary site
Affiliations- Clinical Department of Radiotherapy, Pomeranian Medical University, West Pomeranian Oncology Center, Szczecin, Poland
- Department of Clinical Oncology, West Pomeranian Oncology Center, Szczecin, Poland
- Clinical Department of Radiotherapy, Pomeranian Medical University, West Pomeranian Oncology Center, Szczecin, Poland
- Department of Forensic Medicine, Pomeranian Medical University, Szczecin, Poland
- Faculty of Health and Life Sciences, Northumbria University in Newcastle upon Tyne, United Kingdom
- Pathomorphology Laboratory, 109 Military Hospital with Outpatient Clinic, Szczecin, Poland
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Abstract
The authors present a case of a 49-year-old patient with a trichilemmal carcinoma of an unknown primary site. The groin tumour graduallyenlarged over 6 months to a diameter of about 6 cm and was treated as an inguinal hernia. Specimens were taken from the tumourfor histopathological examination, which revealed squamous cell carcinoma. In the meantime, ulceration of the tumour with leakage ofpus appeared. The patient was referred for a computed tomography (CT) scan. A computed tomography scan exposed enlarged lymphnodes in the groin on the side of the tumour. Surgical treatment was undertaken involving excision of the tumour and a lymphadenectomyalong the iliac vessels. Carcinoma was detected from the hair sheath. Chemotherapy and radiotherapy were undertaken. After fourmonths, there were no signs of local recurrence or distant metastasis. The authors discuss the diagnostic difficulties encountered and thevarious treatment options for trichilemmal carcinoma.
Abstract
The authors present a case of a 49-year-old patient with a trichilemmal carcinoma of an unknown primary site. The groin tumour graduallyenlarged over 6 months to a diameter of about 6 cm and was treated as an inguinal hernia. Specimens were taken from the tumourfor histopathological examination, which revealed squamous cell carcinoma. In the meantime, ulceration of the tumour with leakage ofpus appeared. The patient was referred for a computed tomography (CT) scan. A computed tomography scan exposed enlarged lymphnodes in the groin on the side of the tumour. Surgical treatment was undertaken involving excision of the tumour and a lymphadenectomyalong the iliac vessels. Carcinoma was detected from the hair sheath. Chemotherapy and radiotherapy were undertaken. After fourmonths, there were no signs of local recurrence or distant metastasis. The authors discuss the diagnostic difficulties encountered and thevarious treatment options for trichilemmal carcinoma.
Keywords
trichilemmal carcinoma, metastases, lymph nodes, chemotherapy
About this articleTitle
Trichilemmal carcinoma of the groin area of unknown primary site
Journal
Issue
Article type
Case report
Pages
162-166
Published online
2023-12-12
Page views
363
Article views/downloads
100
DOI
Bibliographic record
Forum Dermatologicum 2023;9(4):162-166.
Keywords
trichilemmal carcinoma
metastases
lymph nodes
chemotherapy
Authors
Krzysztof Kowalik
Katarzyna Hetman
Marta Suchomska
Michał Falco
Anna Gruszczyńska
Krystian Kasperowicz
Jerzy Grabarek
Andrzej Modrzejewski
References (22)- Boscaino A, Terracciano LM, Donofrio V, et al. Tricholemmal carcinoma: a study of seven cases. J Cutan Pathol. 1992; 19(2): 94–99.
- Fronek L, Brahs A, Farsi M, et al. A rare case of trichilemmal carcinoma: histology and management. J Clin Aesthet Dermatol. 2021; 14(6): 25–30.
- Hamman MS, Brian Jiang SI. Management of trichilemmal carcinoma: an update and comprehensive review of the literature. Dermatol Surg. 2014; 40(7): 711–717.
- Tolkachjov SN, Hocker TL, Camilleri MJ, et al. Mohs micrographic surgery in the treatment of trichilemmal carcinoma: the Mayo Clinic experience. J Am Acad Dermatol. 2015; 72(1): 195–196.
- Garrett AB, Azmi FH, Ogburia KS. Trichilemmal carcinoma: a rare cutaneous malignancy: a report of two cases. Dermatol Surg. 2004; 30(1): 113–115.
- Reis JP, Tellechea O, Cunha MF, et al. Trichilemmal carcinoma: review of 8 cases. J Cutan Pathol. 1993; 20(1): 44–49.
- Headington JT. Tumors of the hair follicle. A review. Am J Pathol. 1976; 85(2): 479–514.
- Yi HS, Sym SJ, Park J, et al. Recurrent and metastatic trichilemmal carcinoma of the skin over the thigh: a case report. Cancer Res Treat. 2010; 42(3): 176–179.
- Van Zele D, Arrese JE, Heymans O, et al. Invasive tricholemmal carcinoma of the nose. Dermatology. 2002; 204(4): 315–317.
- Roismann M, de Freitas RR, Ribeiro LC, et al. Trichilemmal carcinoma: case report. An Bras Dermatol. 2011; 86(5): 991–994.
- Mane DR, Kale AD, Hallikerimath S, et al. Trichilemmal carcinoma associated with xeroderma pigmentosa: report of a rare case. J Oral Sci. 2010; 52(3): 505–507.
- Wong TY, Suster S. Tricholemmal carcinoma. A clinicopathologic study of 13 cases. Am J Dermatopathol. 1994; 16(5): 463–473.
- Hamman MS, Brian Jiang SI. Management of trichilemmal carcinoma: an update and comprehensive review of the literature. Dermatol Surg. 2014; 40(7): 711–717.
- Kulahci Y, Oksuz S, Kucukodaci Z, et al. Multiple recurrence of trichilemmal carcinoma of the scalp in a young adult. Dermatol Surg. 2010; 36(4): 551–554.
- Billingsley EM, Davidowski TA, Maloney ME. Trichilemmal carcinoma. J Am Acad Dermatol. 1997; 36(1): 107–109.
- Lai TF, Huilgol SC, James CL, et al. Trichilemmal carcinoma of the upper eyelid. Acta Ophthalmol Scand. 2003; 81(5): 536–538.
- Kim YH, Lee YK, Choi KW, et al. A case of trichilemmal carcinoma treated with mohs micrographic surgery. Ann Dermatol. 2008; 20(3): 157–161.
- Hayashi I, Harada T, Muraoka M, et al. Malignant proliferating trichilemmal tumour and CAV (cisplatin, adriamycin, vindesine) treatment. Br J Dermatol. 2004; 150(1): 156–157.
- Ikegawa S, Saida T, Obayashi H, et al. Cisplatin combination chemotherapy in squamous cell carcinoma and adenoid cystic carcinoma of the skin. J Dermatol. 1989; 16(3): 227–230.
- Bae SB, Lee KK, Kim JS, et al. A case of malignant proliferating trichilemmoma of the scalp with multiple metastases. Korean J Intern Med. 2001; 16(1): 40–43.
- Weiss J, Heine M, Grimmel M, et al. Malignant proliferating trichilemmal cyst. J Am Acad Dermatol. 1995; 32(5 Pt 2): 870–873.
- Cavanagh G, Negbenebor NA, Robinson-Bostom L, et al. Two cases of malignant proliferating trichilemmal tumor (MPTT) and review of literature. R I Med J (2013) . 2022; 105(1): 12–16.
