Vol 7, No 4 (2021)
Case report
Published online: 2022-01-31
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Eosinophilic panniculitits (Wells syndrome) — a case report

Agnieszka Pszczółkowska1, Elżbieta Ostańska2, Adam Reich1
Forum Dermatologicum 2021;7(4):109-112.


 We present the case of a 33-year-old woman in whom recurrent and self-limiting erythemato-edematous lesions, located on the lower limbs and the trunk, have been observed for about 2 years. Physical examination, besides the erythemato-edematous skin lesions, revealed peripheral lymphadenopathy, swollen ankles, and livedo reticularis of the lower limbs and abdomen. In the laboratory tests performed, elevations of inflammatory parameters were noted. The histopathological examination of the skin lesions showed perivascular lymph-granulocytic infiltrates with a predominance of eosinophils; there were also the so-called flame figures present. The diagnosis of Wells’ syndrome was made on the basis of the overall clinical presentation. Systemic corticosteroids were started which allowed to achieve a full control of disease symptoms. 

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  1. Heelan K, Ryan JF, Shear NH, et al. Wells syndrome (eosinophilic cellulitis): Proposed diagnostic criteria and a literature review of the drug-induced variant. J Dermatol Case Rep. 2013; 7(4): 113–120.
  2. Wells GC. Recurrent granulomatous dermatitis with eosinophilia. Trans St Johns Hosp Dermatol Soc. 1971; 57(1): 46–56.
  3. Caputo R, Marzano AV, Vezzoli P, et al. Wells syndrome in adults and children: a report of 19 cases. Arch Dermatol. 2006; 142(9): 1157–1161.
  4. Rajpara A, Liolios A, Fraga G, et al. Recurrent paraneoplastic Wells syndrome in a patient with metastatic renal cell cancer. Dermatology Online J. 2014; 20(6).
  5. Weins AB, Biedermann T, Weiss T, et al. Wells syndrome. J Dtsch Dermatol Ges. 2016; 14(10): 989–993.
  6. Sinno H, Lacroix JP, Lee J, et al. Diagnosis and management of eosinophilic cellulitis (Wells' syndrome): A case series and literature review. Can J Plast Surg. 2012; 20(2): 91–97.
  7. Räßler F, Lukács J, Elsner P. Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review. J Eur Acad Dermatol Venereol. 2016; 30(9): 1465–1479.